摘要
目的:研究重症成人特发性血小板减少性紫癜(ITP)患者的幽门螺杆菌(Hp)感染率以及Hp感染与患者临床特点之间的相关性。方法:应用14C尿素呼气试验(14C-UBT)检测重症ITP患者与对照人群的Hp感染率;比较Hp阳性和Hp阴性ITP患者的年龄、性别、骨髓巨核细胞数及对糖皮质激素治疗的反应。结果:42例ITP患者中28例14C-UBT阳性(66.7%),明显高于正常对照组19%(P<0.01)。Hp阳性和Hp阴性ITP患者糖皮质激素治疗的有效率分别为93%和21%,两组相比差异十分显著(P<0.01)。结论:ITP患者Hp感染率增高,Hp阳性ITP患者对糖皮质激素治疗更敏感。
Objective： To study the incidence of Helicobacter pylor/（Hp） infection in patients with severe idiopathic thrombocytopenic purpura （ITP） and to evaluate the relationship between Hp infection and clinical characteristics of ITP. Methods：The incidence of Hp infection was detected by ^14C-urea breath test （^14C-UBT）in patients with severe ITP and normal controls. The differences in age,sex,megakaryocyte count in bone marrow,and response to glucocorticoid were compared between ITP patients with and without Hp infection. Results：The incidence of Hp infection in patients with severe ITP was significantly higher than that in normal controls （66.7% vs. 19% ,P 〈 0.01 ）. There was significant difference in the response to glucocorticoid between ITP patients with and without Hp infection （93% vs. 21% ,P 〈 0.01 ）. Conclusion：The incidence of Hp infection is high in patients with severe ITP. ITP patients with lip infection are more sensitive to steroid.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2007年第1期96-97,共2页
Journal of China Medical University
