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抗髓过氧化物酶抗体相关肾炎的研究进展 被引量:6

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摘要 抗髓过氧化物酶抗体(myeloperoxidase—antineutrophil cytoplasmic antiboay,MPO—ANCA)相关肾炎是最近提出的新概念,患者血清中有抗中性粒细胞胞质α颗粒内髓过氧化物酶(myeloperoxidase,MPO)的自身抗体MPO—ANCA,病理表现为肾毛细血管及细小血管坏死或肉芽肿性血管炎造成的急进性肾小球肾炎(rapidly progressive glomerulonephfitis,RPGN),临床有血尿、慢性肾炎、慢性肾功能不全。特别是在中老年人有感染症状、贫血、全身倦怠等前驱症状后.再出现RPGN时,首先应该考虑本病。本文就MPO—ANCA相关肾炎的发病机制、临床表现、诊断、治疗及最新进展做一综述。
出处 《中华风湿病学杂志》 CAS CSCD 2007年第3期182-185,共4页 Chinese Journal of Rheumatology
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