摘要
目的 观察住院期间应用他汀类药物对低密度脂蛋白胆固醇（LDL-C）〈2．6mmol／L的冠心病患者血管重建术后住院和随访结果的影响。方法 我院接受血管重建治疗并且LDL—C〈2．6mmol／L的患者1765例，根据住院期间是否应用他汀类药物分为他汀组1056例与非他汀组709例。结果 他汀组院内主要不良心脑血管事件（MACCE）发生率和随访病死率均较非他汀组明显降低（分别为1．7％比3．8％，P=0．006；2．1％比5．1％，P=0．002），他汀组血管重建后累积病死率（院内及随访）也明显低于非他汀组（3．6％比7．9％，P〈0．001）。经logistic多因素回归分析，住院期间是否应用他汀类药物与累积病死率（院内死亡和随访死亡）显著相关（RR：0．597；95％CI为0．360～0．990；P=0．046），并且与随访病死率显著相关（RR：0．436；95％CI为0．231～0．821；P=0．01）。结论 住院期间应用他汀类药物可以显著减少胆固醇不高的冠心病患者血管重建术后的住院不良事件，降低累积病死率及随访病死率。
Objective To observe the influence of statin treatment on coronary heart disease （ CHD ） patients with low-density lipoprotein cholesterol （ LDL-C ） below 2.6 mmol/L who received revascularization. Methods 1765 CHD patients with LDL-C below 2.6 mmol/L who received revascularization in our hospital were selected. The 1056 patients （ statin group ） received statin therapy in hospital and the other 709 patients （ no-statin group ）did not receive statin treatment. Results The occurrence of in-hospital major adverse cardiovascular and cerebralvascular events （ MACCE ） and mortality in the follow-up period was significantly reduced in the statin group as compared with those of no-statin group （ respectively 1.7% vs. 3.8 % ;P = 0.006 and 2.1% vs. 5.1% ;P = 0. 002 ）. Cumulative mortality （ in-hospital and follow-up period （ was also decreased in the statin-group as compared with that of no-statin group （3.6% vs. 7.9% ,P 〈0. 001 ）. In logistic regression analysis,statin treatment initiated in hospital was associated with a reduction in cumulative mortality and mortality of the followed up period （ respectively RR ： 0. 597 ; 95%CI：0.360-0.990;P=0.046 and RR：0.436;95%CI：0.231 -0.821;P=0.01）. Conclusion Statin treatment initiated in hospital is associated with a reduction in hospital MACCE and cumulative mortality and mortality of the followed-up period.
出处
《中国综合临床》
北大核心
2007年第3期198-200,共3页
Clinical Medicine of China
关键词
冠心病
他汀类药物
血管重建
Coronary heart disease
Statin
Revascularization
