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脂联素与2型糖尿病大血管病变的相关性研究 被引量：3

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摘要 目的探讨脂联素与2型糖尿病大血管病变的关系。方法采用酶联免疫吸附法测定了50例正常对照组和100例2型糖尿病患者(包括单纯2型糖尿病者50例和有大血管病变者50例)血清中的脂联素。结果2型糖尿病大血管病变组血清脂联素水平为(3.61±0.72)mg/L,显著低于正常对照组的(6.89±3.28)mg/L(P<0.01)和单纯2型糖尿病组的(4.84±1.92)mg/L(P<0.01)。多元逐步回归分析显示,低脂联素与HOMA-IR、TG、LDL-C、FPG是大血管病变发生的危险因素。结论低脂联素血症是2型糖尿病大血管病变发生发展的独立危险因素。
作者 张如锋 王娟 李智滨
机构地区 河北省石家庄市中医院内分泌科
出处 《临床内科杂志》 CAS 2007年第2期124-125,共2页 Journal of Clinical Internal Medicine
关键词 脂联素 动脉粥样硬化 2型糖尿病
分类号 R587.2 [医药卫生—内分泌]
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参考文献11

  • 1Tsao TS,Lodish HF,Fruebis J.ACRP30,a new hormone controlling fat and glucose metabolism.EJP,2002,440:213-221.
  • 2Ross R.Atherosclerosis is an inflammatory disease.Am Heart J,1999,138(5 pt 2):S419-S420.
  • 3Hotta K,FunahashiT,Arita Y,et al.Plasma concenteations of a novel,adipose-specific protein,adiponection,in type 2 diabetie patients.Arterosler.Thromb Vase Biol,2000,20:1595-1599.
  • 4刘岩,邹大进,李慧,陈月,丁继军,郑兴,郭鹏飞.低脂联素血症是冠状动脉粥样硬化严重程度的重要标志[J].中华内分泌代谢杂志,2005,21(1):5-8. 被引量：112
  • 5Kumada M,Kihara S,Sumitsuji S,et al.Association of determining the severity of coronary heart disease.Am J Cardiol,1983,51:606-609.
  • 6Hotta k,Funahashi T,Bodkin NL,et al.Circulating concentrations of the adipocyte protein adiponectin are decrased in parallel with reduced insulin sensitivity during theprogression to type 2 diabetes in rhesus monkeys.Diabetes,2001,50:1126-1133.
  • 7Lindsay RS,Funahashi T,Hanson RL,et al.Adiponectin and development of type 2 diabetes in Pima Indian population.Lancet,2002,360:57-58.
  • 8Valsamakis G,Chetty R,Mcteman PG,et al.Fasting serum adiponectin cocentration is reduced in Indo-Asian subjects and is related to HDLcholesterol.Diabetes Obes Metab,2003,5:131-135.
  • 9洪洁,顾卫琼,张翼飞,唐金凤,杨颖,陈宇红,孙首悦,赵咏桔,宁光.胰岛素抵抗综合征患者血清脂联素和胰岛素敏感性的相关性研究[J].中华内分泌代谢杂志,2003,19(3):173-176. 被引量：93
  • 10Arita Y,Kihara S,Ouchi N,et al.Paradoxical decrease of an adipose-specific protein,adiponectin,in obesity.Biochem Biophys ResCommun,1999,257:79-83.

二级参考文献45

  • 1刘军,陈影,刘芳,姚庆姑,许火根,澎名淑,郭瑜琳,陈钦达.2型糖尿病家系非糖尿病一级亲属脂联素水平与胰岛素抵抗和动脉粥样硬化相关性研究[J].中华内分泌代谢杂志,2004,20(3):215-216. 被引量：30
  • 2Hotta K, Funahashi T, Arita Y, et al. Plasma concentration of a novel,adipose-specific protein, adiponectin, in type 2 diabetic patients.Arterioscler Thromb Vasc Biol, 2000,20 : 1595-1599.
  • 3Bergman RN. Toward physiological understanling of glucose tolerance.Minimal-model approach. Diabetes, 1989,38 : 1512-1527.
  • 4Kondo H, Shimomura I, Matsukawa Y, et al. Association of adiponectin mutation with type 2 diabetes. A candidate gene for the insulin resistance syndrome. Diabetes, 2002,51:2325-2328.
  • 5Arita Y, Kihara S, Ouchi N, et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun, 1999,257:79-83.
  • 6Hotta K, Funahashi T, Bodkin N, et al. Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in Rhesus monkeys. Diabetes, 2001,1126-1133.
  • 7Weyer C, Funahashi T, Tanaka S, et al. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab, 2001,86 : 1930-1935.
  • 8Maeda K, Okubo K, Shimomura I, et al. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (Adipose most abundant gene transcript 1 ). Biochem Biophys Res Commun, 1996,221:286-289.
  • 9Scherer PE, Williams S, Fogliano M, et al. A novel serum protein similar to Clq, produced exclusively in adipocytes. J Biol Chem,1995,270 : 26746 -26749.
  • 10Vasseur F, Helbecque N, Dina C, et al. Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians.Hum Mol Genet, 2002,11:2607-2614.

共引文献275

同被引文献42

  • 1王明海,于振海,张曙光,李光新,秦士勇,王坤.踝肱指数在下肢动脉缺血性疾病中的临床应用[J].中国血管外科杂志（电子版）,2011,3(1):59-61. 被引量：7
  • 2吕青山,谢秀梅,陈晓彬,谢晓华,孙国举.瘦素水平与冠心病及其相关危险因素的关系[J].医学临床研究,2006,23(12):1914-1916. 被引量：2
  • 3李嘉强,戴颖秀,刘玉敏,郑基,刘文斌.代谢综合征不同组分患者血清脂联素与游离脂肪酸谱代谢参数的比较[J].中国糖尿病杂志,2007,15(6):323-326. 被引量：5
  • 4Grundy SM. Hypertriglyceridemia, insulin resistance,and the metabohc syndrome [ J ]. Am J Cardiol, 1999,83 ( 9 ) :25-29.
  • 5Lakka HM, Laaksonen DE, Lakka TA, et al. The metabolic syndrome and total and cardiovascular disease mortality in middleaged men [ J ]. JAMA,2002,288 ( 21 ) :2709-2716.
  • 6Ferrannini E. Is insulin resistance the cause of the metabolic syndrome[ J]. Ann Med,2006,38( 1 ) :42-51.
  • 7Eckel RH, Grundy SM, Zimmet PZ. The metabolic syndrome [ J ]. Lancet ,2005,365 (9468) : 1415-1428.
  • 8Cleeman JT. Executive Summary of the third report of the national cholesterol education program( NCEP )expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel Ⅲ ) [ J]. JAMA ,2001,285 ( 19 ) :2486-2497.
  • 9Cnop M, Vidal J, Hull RL,et al. Progressive loss of beta-cell function leads to worsening glucose tolerance in first-degree relatives of subjects with type 2 diabetes [ J ]. Diabetes Care, 2007,30 ( 3 ) : 677-682.
  • 10Sever PS, Dahlsf B, Poulter N,et al. Potential synergy between lipid-lowering and blood-pressure-lowering in the Anglo-Scandinavian Cardiac Outcomes Trial [ J ]. Eur Heart J, 2006, 27 ( 24 ) : 2982-2988.

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临床内科杂志
2007年 第2期

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