摘要
目的评价突发性聋的治疗方法的疗效及安全性,对突发性聋进行循证治疗。方法通过循证医学评价数据库、PubMed、中文科技期刊数据库、中国期刊全文数据库等机检索,并通过人工检索8种中文耳鼻咽喉科学杂志,选择治疗突发性耳聋的随机对照试验进行分析。结果关于激素、高压氧、扩血管和针灸治疗的4篇系统评价表明以上方法的疗效未明确,而且要防止治疗的不良反应。另外还有随机对照试验文献11篇和有循证医学倾向的系统综述5篇。设有安慰剂双盲对照的文献只有8篇。结论根据研究证据制定突聋的治疗原则:药物治疗应以缓解症状和保护内耳为主,避免耳蜗再被损伤,促进听力恢复。治疗4例中度以上听力损失的突聋患者,疗效满意。
Objectives To evaluate curative effect and safety of the treatment method about idiopathic sudden sensorineural heating loss （ISSHL）, following an evidence-based therapy. Methods Search ISSHL in electronic database： Evidence-Based Medical Review Database, PubMed, Chinese Science and Technology Periodical Database, Chinese Periodical Full Text Database, etc., and inspect 8 kinds of science magazines of the Chinese Otolaryngol through a hand search, choose the treatment of random/zed controlled trials （RCT） for ISSHL and carry on analysis. Result As for steroid, hyperbaric oxygen therapy, vasodilator and acupuncture 4 systematic reviews of treatment to express the curative effect of the above methods remained unclear, and prevention from their potential adverse reactions was needed. Still other 11 RCT and 5 evidence-based medical tendency reviews were found. There were only 8 trials that had a placebo double blind RCT. Conclusions The above-mentioned proof draws up the treatment principle of ISSHL：the medical treatment should prioritize alleviating symptoms and protecting inner ear, avoiding cochlear ischemic re-injury, and promote hearing recover. Cured 4 cases with moderate degree and above of sudden sensorineural hearing loss, followed up for 1-3 months, with 3 cases compleetly recovered, and 1 partly recovered.
出处
《循证医学》
CSCD
2007年第1期26-30,共5页
The Journal of Evidence-Based Medicine
关键词
聋
突发性
随机对照试验
循证医学
系统评价
deafness, sudden
randomized controlled trials
evidence-based medicine
systematic reviews
