摘要
目的通过微波辐照后SD大鼠甲状腺和血清T3、T4的动态观察,以初步探讨微波辐照对甲状腺形态和功能的影响。方法二级SD雄性大鼠分高剂量(65w/cm2)低剂量(5w/cm2)两组微波连续辐照两周,每天20min,于辐照的1d、7d、14d和辐照后第4天分别取甲状腺做HE染色;采腹主静脉血用放免法测血清T3、T4的浓度,所有数据经Excel处理。结果大鼠辐照后,高剂量组可见甲状腺随辐照天数增加,病理变化逐渐增重,血清T4在1d时升高(P<0.05)、后浓度逐渐下降,于辐照14d最低(P<0.01),辐照后第4天有所恢复,血清T3浓度逐渐下降,于辐照14d最低(P<0.05);低剂量组甲状腺有轻微病理变化,血清T4在辐照期有下降,但在辐照后第4天有显著性升高(P<0.01)、血清T3随辐照天数增加浓度逐渐下降,但差异无显著性。结论微波连续辐照能引起大鼠甲状腺病理损伤和血清甲状腺激素水平紊乱。
Objective To study the effect of Microwave on thyroid gland and T3 ,T4 in Blood Serum. Methods After exposure to 65w/cm^2 and 5w/cm^2 microwave, changes of thyroid gland in rats were detected by HE stain and T3 ,T4 in blood serum was examined by radioimmunoassay. Result In 65 w/cm^2 irradiation group, the physiological damage was developing with the days of the irradiation. And the T4 blood serum concentration increased on the 1 d irradiation, but decreased gradually during the last irradiation and reached to the lowest point at the 14th day. T3 decreased gradually during the radiation. In 5 w/ cm^2 microwave irradiation group,only slight physiological changes were found. T4 decrease during irradiation but increased significantly at the 4th day after irradiation. T3 level decreased gradually during the irradiation while there was no statistical difference. Condusion The results showed that the continued microwave irradiation can induce changes of thyroid gland and T3 , T4 in blood serum.
出处
《中国辐射卫生》
北大核心
2007年第1期28-30,共3页
Chinese Journal of Radiological Health
基金
国家自然科学基金项目(批号:30676490)
关键词
微波
甲状腺
T3
T4
Microwave
Thyroid Gland
T3
T4
