摘要
目的探讨改构型酸性成纤维细胞生长因子(modified aFGF,MaFGF)对大鼠肾缺血/再灌注损伤的影响。方法Wistar大鼠32只,随机分为4组,即假手术组、模型组、MaF-GF1组(8μg.kg-1)和MaFGF2组(16μg.kg-1),每组8只。以肾缺血/再灌注损伤为模型,通过光、电镜观察肾组织病理变化。结果MaFGF能明显减轻肾组织水肿、间质浸润以及肾小管扩张与破坏,电镜下见肾小管上皮细胞内细胞器(微绒毛、线粒体、溶酶体等)损伤较轻或基本正常。结论MaFGF对大鼠肾缺血/再灌注损伤有一定的保护作用。
Aim To study the protective effect of modified acidic fibroblast growth factor （MaFGF） on renalischemia/reperfusion injury of rats. Methods 32 Wistar rats were divided randomly into four groups;false operative control group, model control group, 8 μg· kg^-1 of MaFGF and 16 μg· kg^-1 of MaFGF groups with 8 animals in each group. Renal pathological changes were observed by light and electron microscope. Results As shown in pathology, compared with model control group, MaFGF group could significantly reduce edema, number of leukocytes appearing in the interstitium , distention and destroy of renal tissues. Under EM, the ultrostructure （including mi-crovilli, mitochondria and lysosomes etc. ） of the tubular epithelial cells of MaFGF groups appeared lighter in injuries or even near normal. Conclusion MaFGF has a role in attenuation of renal damage or failure after ischemia-reperfusion injury of the kidney.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2007年第2期166-169,共4页
Chinese Pharmacological Bulletin
基金
国家重点基础研究发展规划(973规划)资助项目(NoG199954204)
