摘要
目的 观察熊去氧胆酸片联合胆维他片及单独山莨菪碱治疗肾移植术后环孢素性肝损害的疗效，寻找有效的治疗方法．方法 将肾移植术后28例环孢素性肝损害患者分为两组，A组：口服熊去氧胆酸片50mg，tid胆维片25mg，tid；B组：山莨菪碱40mg加入5％葡萄糖注射液中，每天一次静点或10mg每日4次口服，疗程1～3个月．结果A组16例中有15例治愈（占93．8％），1例好转（占6．3％）；B组12例中3例好转（25．0％），9例无效（占75．0％）。结论 熊去氧胆酸与胆维他联合应用肾移植术后环孢素所致肝损害疗效明显优于山莨菪碱．
Objective To evaluate the curative effect of between ursodeoxycholic acid in combination with felviten and ansiodamine on ciclosporin-induced hepatic lesion in renal transplant recipients .Methods Twenty-eight renal transplant recipients with nephroxicity induced by CsA were randomly divided into tow groups. Group A（n=16） recived felviten （25mg, tid） abd yrsideixtcgikuc acud （50mg, tid）; Group B（n=12） recived anisodamine intravenously （40mg in 5% glucose injection, once a day） or orally （lOmg, 4 times a day ） for 1-3 months. Results In group A93.8%（15,16） of the patients were cured and 6.3%（1/16） improved. In group B, 25A%（3/12） of the patients were improved and 75.0%（9/12） inefficacy Conclusion Combination ursodeoxycholic acid and felviten was much more effects than anisodamine in treatment on ciclosporin-induced hepatic lesion in renal transplant recipients.
出处
《国际医药卫生导报》
2007年第3期39-41,共3页
International Medicine and Health Guidance News
关键词
熊去氧胆酸
胆维他
肾移植
环孢素
肝损害
Felviten Ursodeoxycholic acid Kidney transplantation Ciclosporin Hepatic lesion
