摘要
目的:分析国内文献资料中阿莫西林不良反应报告的情况,探索阿莫西林不良反应的发生规律和特点。方法:阿莫西林药物不良反应(ADR)病例通过检索中国生物医学文献数据库和中国医院知识仓库获得,对检索到的符合条件的阿莫西林ADR资料进行计量统计学分析。结果:共检索出175例阿莫西林ADR病例报告,ADR临床表现列前3位的分别是皮肤及其附件损害、全身性损害和泌尿系统损害,共占阿莫西林不良反应的80.58%。有3例过敏性休克病人死亡。结论:过敏反应是阿莫西林最常见的严重不良反应,加强病人药物过敏史、过敏性疾病史的询问和首剂用药的观察对于预防阿莫西林引发过敏反应、减少阿莫西林不良反应的发生具有重要意义。
Objective： To explore the general pattern and characteristics of amoxicillin-induced adverse drug reactions （ADR） reported in China. Methods： Chinese Hospital Knowledge Databases （CHKD） and Chinese Biomedical Database （CBM） were searched with key words for case reports of amoxicillin ADR, and the obtained references were analyzed based on present criteria. Results： There were 175 case reports meeting the analysis requirements,The clinical manifestations of amoxicillin-induced ADR were mainly involved with （80.58 %） skin and appendages disorders, general body disorders, and urinary system disorders. There were 3 patients died of anaphylactic shock. Conclusion： The most frequent serious ADR ofamoxicillin is anaphylaxis, To reduce amoxillin-induced ADR, it is very important for clinicians to pay more attention to the inquiry of history of allergic drug, and allergic disease, and to the observation of the patients when they take the first dose of amoxicillin.
出处
《抗感染药学》
2007年第1期31-35,共5页
Anti-infection Pharmacy
