摘要
目的:考察光照对尼群地平固体分散体微丸体外溶出行为的影响。方法:将以PEG6000、PVPk30、F68和PVPk30/F68为载体的微丸4种尼群地平固体分散体微丸,分别置于日光灯3000Lx、自然光下照射,于0,5,10d取样,通过体外溶出度试验考察微丸中药物的溶出行为变化。结果:在日光灯3000Lx和自然光照射下,4种尼群地平固体分散体微丸的体外溶出速度均有下降,自然光的影响更为显著。几种微丸中,以F68微丸对光的稳定性最好,自然光照10d后药物的60min累积溶出百分率仍在80%以上。结论:可采用F68作为可溶性载体材料制备尼群地平固体分散体微丸,稳定性较好。
Objective： To investigate the effect of illumination on in-vitro dissolution behavior of nitrendipine solid dispersion pellets. Methods： Four pellets of PEG 6 000, PVPk30, F 68 and PVPk30/F 68 were illuminated by lamp with 3000 Lx and daylight, respectively. Then dissolution behaviors of nitrendipine from the pellets sampled from these illuminated were investigated by dissolution test, Results： Dissolution behavior in-vitro of nitrendipine dissolved from four pellets was all decreased and the effect of daylight was more obvious, F 68 pellets were affected least and the percentage of drug dissolved in 60 min was more than 80% when illuminated 10 days through daylight. Conclusions： Nitrendipine solid dispersion pellets will have a fine stability when F 68 is added in formulation.
出处
《抗感染药学》
2007年第1期9-10,30,共3页
Anti-infection Pharmacy
关键词
尼群地平
光照
稳定性
溶出试验
Nitrendipine
illumination
stability
dissolution test
