摘要
目的：从胃癌形态学方面，探讨辽宁省庄河地区胃癌高发区胃癌病理形态学特征及其年代变化趋势，探讨这种变化与胃癌发病影响因素之间的关系，为胃癌防治提供线索和依据。方法：选取1992-2005年在辽宁庄河市中心医院接受手术切除的胃癌标本共计1003例。标本均经4％甲醛固定，病理常规系统检查。结果：1003例胃癌患者平均发病年龄58．9岁（17～84岁）；不同年代胃癌高发年龄均为60～69岁，其次为50～59岁，男性胃癌患者明显多于女性患者（P〈0．001），男女患者之比为3．0：1。1003例胃癌患者中，共检出早期胃癌159例（15．9％），年均构成比为15．3％，中期胃癌195例（19．4％），晚期胃癌649例（64．7％）。各年间早期胃癌大体分型以Ⅲ型为主；进展期胃癌以BorrmannⅢ型为主。在淋巴结转移方面，早期胃癌各年间无淋巴结转移者多于有淋巴结转移者；进展期胃癌各年间有淋巴结转移者多于无淋巴结转移者。在组织学分型方面，乳头状管状腺癌、中分化管状腺癌、低分化管状腺癌和印戎细胞癌呈逐年下降趋势；黏液腺癌、未分化癌呈逐年升高趋势；若以Lauren分类为标准，在各年代间均以弥漫型胃癌占优势，并呈逐年上升趋势，肠型胃癌呈下降趋势，二者比值呈下降趋势。结论：随着年代的变迁，庄河地区胃癌临床流行病学特征有明显变化。
To explore the pathological features and chronological changes of 1 003 cases of gastric cancer in Zhuanghe high-risk area from 1992-2005 and the relationship between the changes and etiology factors in order to make a clue for gastric cancer prevention. METHODS： A total of 1 003 gastric cancer specimens resected surgically between 1992 and 2005 in Zhuanghe Center Hospital were studied. The specimens were fixed in formalin and diagnosed by routine pathology. RESULTS： The incidence of patients with gastric cancer was highest at age of 60-69,the next was at age of 50-59 and it was significantly higher in male than in female （P〈0. 001）, the ratio was 3.0 ： 1. During the past 14 years, there were 159 cases （15. 90%） early gastric cancer detected, the annual average constituent ratio was 15.3%, and there were 195 cases （19.4%） moderate and 649 cases （64. 7%） advanced gastric cancer detected. In macroscopical features, Ⅲ type remained the dominant type in early gastric cancer, in advanced gastric cancer the Borrmann＇s type Ⅲ remained the dominant. In lymphaticmetastasis in early gastric cancer, moreover positive cases were higher than negative ones each year. In advanced cancer positive cases were higher than negative ones each year. In histological features mastoid, moderately differentiated and poorly differentiated tubular adremained downtrend year after year, mucus adenocarci noma and undifferentiation cancer remained uptrend year after year. The ratio of intestinal to diffuse type of gastric cancer decreased from 0. 78 to 0. 62 during the past 14 years. CONCLUSION： There are significant fentures of gastric cancer clinical epidemiology in Zhuanghe area by chronological changes.
出处
《中华肿瘤防治杂志》
CAS
2007年第2期96-99,共4页
Chinese Journal of Cancer Prevention and Treatment
基金
国家“十五”科技攻关项目(2001BA703806(B),2004BA703804-02)
关键词
胃肿瘤/病理学
胃肿瘤/流行病学
庄河/流行病学
回顾性研究
stomach neoplasms/pathology, stomach neoplasms/epidemiology
zhuanghe/epidemiology, retrospec-tive studies
