摘要
目的:研究大豆甙元磺酸钠对胃运动的影响及其作用机制。方法:采用SD大鼠腹腔和侧脑室给药,记录胃运动收缩的幅度和频率。结果:①腹腔注射不同剂量的大豆甙元磺酸钠,均引起胃收缩幅度下降,但未呈现剂量效应关系;胃收缩频率无明显变化。②腹腔注射纳洛酮可反转大豆甙元磺酸钠的作用。③腹腔注射心得安,可使大豆甙元磺酸钠抑制胃运动的作用增强,注射酚妥拉明可反转大豆甙元磺酸钠的作用。④腹腔注射阿托品对大豆甙元磺酸钠的作用无明显的影响。⑤侧脑室注射不同剂量的大豆甙元磺酸钠,其中小剂量组出现胃收缩幅度下降,但胃收缩频率亦无明显变化。结论:腹腔和侧脑室注射大豆甙元磺酸钠对胃运动均有抑制作用,且腹腔注射大豆甙元磺酸钠的效应至少部分是与内源性阿片肽及其受体和去甲肾上腺素能神经元及其α受体有关,肾上腺素能神经元及β肾上腺素能受体也参与了大豆甙元磺酸钠抑制胃运动的作用。
Aim： To explore the effect of sodium 4＇, 7-bihydroxylisoflavone-sulfonate（SBIS） on gastric motility in rats and to analyse its meehanisim. Methods： Using intraperitoneal（ip） injection and intracerebroventriular（icv） microinjection of drugs and recording the frequency and amplitude of contraction of gastric motility. Results：①The injection（ip） of different doses of SBIS could decrease the amplitude of gastric motility, but it wasn＇ t a dose-dependent effect. SBIS also had no effect on the frequency of contraction. ②The ip injection of naloxon reversed the inhibitory effect of SBIS on the amplitude of gastric contraction. ③The effect of SBIS could be increased by the ip injection of propranolol and be reversed by the ip injection of phentolamine. ④After the ip injection of atropine, the effect of SBIS on gastric motility had not been changed remarkably. ⑤ Different dosess of SBIS had been microinjected（icv）, but only the small dose decreased the amplitude of gastric motility and also the frequency of contraction had not been markedly changed. Conclusion： Both the i. p. and icv injection of SBIS can inhibit the gastric motility. Its effect can be achieved at least not only by endogenous opioid peptide and its receptors, but also adrenergic neuron and its α-receptors. Adrenergic neuron and its β-receptors are also involved in the modulating effect of SBIS.
出处
《中国应用生理学杂志》
CAS
CSCD
北大核心
2007年第1期106-110,共5页
Chinese Journal of Applied Physiology
基金
陕西省自然科学基金资助项目(39111)
关键词
大豆甙元磺酸钠
胃运动
sodium 4＇ 7-bihydroxylisoflavone β-sulfonate
gastric motility
