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胰肾联合移植的现状及进展 被引量:1

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摘要 成功的胰肾联合移植(simultaneous pancreaskidney transplantation,SPK)能同时治疗糖尿病及其并发的终末期肾病,使患者术后具有正常的内分泌功能和生理性调节能力,从而阻止甚至逆转糖尿病及其并发症的进展,因此是终末期糖尿病患者有效的治疗方法。自从1967年Kelly等报道为一例Ⅰ型糖尿病继发肾功能不全患者行胰肾联合移植术以来,伴随器官保存技术的发展、手术方式的日臻完善、新型免疫抑制剂的临床应用和移植免疫学的新发现以及术后管理、监测方法的进步,SPK经历了近40年的风雨变迁。目前,SPK术后移植物和受者生存率明显提高,相关并发症进一步减少,受者的生存质量大大改善,使得该手术已被大家广泛认可,并在全球范围开展。
作者 郑树森 严盛
出处 《中华外科杂志》 CAS CSCD 北大核心 2007年第5期298-300,共3页 Chinese Journal of Surgery
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