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心脏选择性部位起搏的电和机械同步性研究的初步报告 被引量:17

Report on initiating clinical research for electrical and mechanical synchronism of selective region pacing in the right ventricular
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摘要 目的观察心脏不同部位起搏时的电及机械同步性和血流动力学变化。方法 14例患者分别于右室心尖(RVA)、希氏束部位(His)、右室高位流出道间隔部(RVOT)起搏,记录心输出量和心脏指数;比较不同部位起搏和自身心律时12导联体表心电图的 QRS 波宽度和方向,以评价电同步性;用全数字化超声诊断系统的向量速度显像评价机械同步性。结果心输出量和心脏指数在RVA 起搏时较差,但差异无统计学意义(P>0.05)。各部位起搏时 QRS 波的宽度:His 为(124±5.3)ms,RVOT(144±7.1)ms,RVA(156±8.6)ms,均较自身心律(92±4.5)ms 时宽(P<0.01);而His 及 RVOT 均较 RVA 起搏时的 QRS 波时限窄,其差异有统计学意义(P<0.01)。向量速度显像检查提示,RVOT 起搏相对于 RVA 起搏有更好的机械同步性。结论 RVOT 可能较传统的 RVA 部位起搏好,同时手术操作容易。 Objective To verify the electric synchronism, mechanic synchronism and hemedynamics of selective site pacing. Methods Pacing in the right ventricular cardiac apex ( RVA), the right ventricular His bundle region (His) , and the septum of right ventricular high-positioned outflow tract (RVOT), CO and CI were recorded. The electrical synchronism was assessed by observing the width and shape in a 12-lead surface ECG . The mechanical synchronism was estimated by using the VVI (vector velocity imaging) technology of the Acuson Sequia 512. Results The results showed that CO and CI were lower while pacing in RVA, but they were not significant different (P 〉0.05). The QRS width: ( 124 ±5.3 ) ms while pacing in His, ( 144 ± 7. 1 ) ms while pacing in RVOT and ( 156 ± 8.6) ms while pacing in RVA. The QRS width while pacing in His and in RVOT were narrower than in RVA and there were significant differences (P 〈 0. 01 ). Vector velocity imaging showed that mechanical synchronism was better while pacing in RVOT than that in RVA. Conclusion Pacing in RVOT seems better than pacing in traditional RVA, and the operation was no more difficult than the traditional operation.
出处 《中华心血管病杂志》 CAS CSCD 北大核心 2007年第2期147-150,共4页 Chinese Journal of Cardiology
关键词 心脏起搏 人工 心脏功能试验 血液动力学 Cardiac pacing, artificial Heart function tests Hemodynamics
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参考文献6

  • 1Henning RA,Jens CN,Poul EBT,et al.Long-term follow-up of patients from a randomized trial of atrial versus ventricular pacing for sick-sinus syndrome.Lancet,1997,350 (25):1210-1216.
  • 2Michael OS,Ann SH,Kenneth AE,et al.Adverse effect of ventricular pacing on heart failure and atrial fibrillation among patients with normal baseline QRS duration in a clinical trial of pacemaker therapy for sinus node dysfunction.Circulation,2003,107(23):2932-2937.
  • 3Charles RK,Stuart JC,Hoshiar A,et al.Canadian trial of physiological pacing during long-term follow-up.Circulation,2004,109(3):357-362.
  • 4McGavigan AD,Mond HG.Selective site ventricular pacing.Curr Opin Cardiol,2006,21(1):7-14.
  • 5Manolis AS.The deleterious consequences of right ventricular apical pacing:time to seek alternate site pacing.Pacing Clin Electrophysiol,2006,29 (3):298-315.
  • 6郭继鸿.生理性起搏及临床应用[J].心血管病学进展,2006,27(2):144-148. 被引量:25

二级参考文献5

  • 1Barold SS,Mugica J.The fifth decade of cardiac pacing[M].1st ed.New York:Blackwell Publishing,Inc./Futura Division,2004.63-75.
  • 2Henning RA,Jens CN,Poul EBT,et al.Long-term follow-up of patients from a randomised trial of atrial versus ventricular pacing for sick-sinus syndrome.[J].Lancet,1997,350 (25):1210-1216.
  • 3Michael OS,Ann SH,Kenneth AE,et al.Adverse effect of ventricular pacing on heart failure and atrial fibrillation among patients with normal baseline QRS duration in a clinical trial of pacemaker therapy for sinus node dysfunction[J].Circulation,2003,107:2932-2937.
  • 4Charles RK,Stuart JC,Hoshiar A,et al.Canadian trial of physiological pacing effects of physiological pacing during long-term follow-up[J].Circulation,2004,109:357-362.
  • 5Toff WD,Camm AJ,Skehan JD,et al.Single-chamber versus dual-chamber pacing for high-grade atrioventricular block[J].N Engl J Med,2005,353:145-155.

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