摘要
目的：观察髓芯减压加自体多能干细胞、脱钙骨基质（DBM）植入治疗早期股骨头坏死的疗效。方法：采用髓芯减压加自体多能干细胞、DBM植入术治疗股骨头缺血性坏死80例（96髋），男43例，女37例；单髋64例，双髋16例；年龄21～62岁，平均38．4岁；病史8个月～3年，平均1．4年。按ARCO分期标准：Ⅰ期62髋，Ⅱ期34髋。根据术前术后症状、髋关节功能评分、X线及CT结果进行评价，分析其疗效。结果：随访超过2年的52例（61髋）中46髋效果明显，10髋病情缓解，5髋病情无进展，优良率为91．8％（56／61）。髋关节Harris评分由术前平均（49、1±7．5）分增至术后平均（75．2±5．9）分，差异有显著性统计学意义（P〈0．01）。结论：髓芯减压加自体多能干细胞、DBM植入术是治疗早期股骨头坏死的一种有效方法。
Objective： To study therapeutic results of core decompression combined with implantation of self-multipotent stem cell and decalcified bone matrix （DBM） for early femoral head necrosis. Methods： Among 80 patients with early femoral head necrosis （96 hips）,43 patients were male and 37 patients were female, age ranging from 21 to 62 years（ average of 38. d years）. Unilateral head necrosis occurred in 64 hips and bilateral head necrosis occurred in 16 hips. The average medical history was 1.4 years ranging from 8 months to 3 years. According to standard of ARCO staging,62 hips were stage Ⅰ and 34 hips were stage Ⅱ. All the patients were treated with core decompression combined with implantation of self-multipotent stem cell and DBM. Clinical effect was analyzed according to clinical symptoms, the score of hip joint function, the films of X-ray and CT before and after operation. Results： Fifty-two patients （61 hips）were followed up more than 2 years. Forty-six hips obtained excellent results, 10 hips got relief of clinical symptom ,5 hips had no improvement, the rate of excellent and good was 91.8% （ 56/61 ）. The averagely Harris score increased from preoperative 49. 1 ± 7.5 to postoperative 75.2 ± 5.9 （P 〈0. 01）. Conclusion： Core decompression combined with implantation of self-multipotent stem cell and DBM is an effective method for early femoral head necrosis.
出处
《中国骨伤》
CAS
2007年第1期15-16,共2页
China Journal of Orthopaedics and Traumatology
关键词
股骨头坏死
髓芯减压
多能干细胞
脱钙骨基质
Femoral head necrosis： Core decompression
Multipotent stem cell
Decalcified bone matrix
