摘要
目的:探讨玉米须总皂苷对病因性糖尿病小鼠模型的降糖作用。方法:采用静脉注射小剂量的四氧嘧啶加灌服葡萄糖造小鼠病因性糖尿病模型,通过血糖、血清胰岛素、胰岛细胞病理改变观察小鼠玉米须总皂苷对其影响。结果:玉米须总皂苷对该模型有较好降糖作用,且对胰岛损伤有较好的改善作用。结论:玉米须总皂苷对本糖尿病模型有较好的治疗作用。
Objective： To observe the effects of Saponin Extracted from Zea Mays L （ZMLS） on reducing blood sugar in pathogenic diabetic mouse models. Methods： The pathogenic diabetic mouse models were established successfully by intravenous injection of small dose of alloxan and intragastric administration of glucose. Modeling state of pathogenic diabetic mice and the effects of Saponin Extracted from Zea Mays L （ZMLS） on pathogenic diabetic mouse models were observed through the levels of blood sugar and serum of insulin and the pathology changes of islet cells. Results ： It was successful to establish pathogenic diabetic mouse models by intravenous injection of small dose of alloxan and intragastric administration of glucose. ZMLS had good action of lowering the level of blood glucose on this model and had good action of preventing the pancreatic island β-cell from the injury induced by drugs. Conclusion： ZMLS has good therapy effects on pathogenic diabetic mouse models induced by intravenous injection of small dose of alloxan and intragastric administration of glucose
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2007年第3期181-183,共3页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
教育部新世纪优秀人才支持计划(No.NCET-04-0657)
河南省高等学校创新人才培养工程(No.2004-23)
