摘要
目的了解东莞市艾滋病的流行病学特征、传染来源及危险因素,推断其流行趋势,为制定防制策略提供依据。方法使用描述性流行病学分析方法对1991-2005年间东莞市的艾滋病常规及哨点监测资料进行分析;使用酶联免疫吸附实验(ELISA)法对不同人群进行HIV抗体检测,阳性者使用蛋白印迹法(WB)确认;采集HIV感染者外周血淋巴细胞提取核酸后用巢式-聚合酶琏反应(PCR)技术对HIV-1env基因进行序列分析、鉴定病毒亚型。结果东莞市自1991年发现首例输入性HIV感染者以来,到2005年底共检出HIV感染者759例,HIV感染者报告数呈现逐年增长趋势;发现的HIV感染者以青壮年、男性、流动人口为主;感染的主要途径是静脉吸毒;CRF01-AE亚型为主要流行株。结论东莞市艾滋病流行已进入快速增长期,并正逐步从吸毒人群和性乱人群向普通人群扩散,防制形势严峻,应进一步加大监测力度并开展针对高危人群的干预措施。
Objective The present study was conducted to find out the epidemiological characteristics, sources of infection and risk factors of AIDS, and deduce the epidemic trend of AIDS in Dong- guan City in order to provide the basis for the prevention and control measures. Methods Descriptive epidemiological methods were used to analyze the routine and sentinel surveillance data of AIDS in Dongguan City from 1991 to 2005. HIV antibody testing was conducted for different populations by ELISA method, and the HIV-positive persons were confirmed by WB. The sequence of HIV-lenv gene was analyzed and the subtype of HIV was identified by nested-PCR after nucleic acid was extracted from lymphocytes of peripheral blood of HIV carriers. Results Since the first imported HIV- infection was found in Dongguan City in 1991, 759 HIV-infected cases had been reported by the end of 2005. The number of reported HIV infections increased year by year. Most of the carders were young, male, and floating ones. Intravenous drug abuse was the main transmission route. The CRF01- AE subtype was the main epidemic strain. Conclusion The prevalence of AIDS has been in the rapidly increasing period, and AIDS is spreading from drug addicts and the population with sexually promiscuous behaviors to general population. It is urgent to strengthen HIV surveillance and develop intervention programs in high-risk populations.
出处
《疾病监测》
CAS
2007年第1期6-9,共4页
Disease Surveillance
关键词
HIV/AIDS
流行病学
监测
human immunodeficiency vires/acquired immunodeficiency syndrome
epidemiology
surveillance
