摘要
目前认为胃肠动力异常和内脏感知障碍、胃肠分泌异常是肠易激综合征(IBS)产生的主要的病理生理机制。大量的动物实验和临床试验已证实5-羟色胺(5-HT)及其受体参与IBS的病理生理机制,并发挥重要的作用。随着对其研究的深入,使用5-HT受体调节剂治疗IBS已成为热点。本文简要综述5-HT受体及其特异性调节剂在IBS中的作用机制及临床疗效。
The main pathophysiological mechanisms of irritable bowel syndrome （IBS） are abnormal stomach intestine mobility, disturbance of internal organ perception and parasecretion of stamach intestine. A growing body of evidence from the animal experiments and clinical trials suggest that 5- hydroxytryptamine （5-HT） and its specific receptors play a key role in the pathophysiological mechanism of IBS. With the further study, it is becoming a hot spot to apply its receptor regulation agents to treat IBS. This article reviews 5-HT receptor and its specific regulator about its action of mechanism and clinical effect in IBS.
出处
《医学综述》
2007年第5期398-400,共3页
Medical Recapitulate
关键词
肠易激综合征
5-羟色胺受体
5-羟色胺受体拮抗剂
5-羟色胺受体激动剂
Irritable bowel syndrome
5-hydroxytryptamine receptor
5-hydroxytryptamine receptor antagonist
5-hydroxytryptamine receptor agonist
