摘要
中期因子(MK)是一种新的肝素结合生长因子,能够促进细胞的生长分化。近年的研究显示,MK在人类正常组织中不表达或低表达,却特异性表达在多种肿瘤组织中,它表达的上调提示肿瘤患者的生存期缩短和预后不良,因此MK可能成为新的肿瘤标记物。应用新的分子生物学技术MK可能成为基因治疗的新靶点。
Midkine （MK） is a new heparin-binding growth factor, which can promote cell growth/differentiation. Midkine is negatively or lowly expressed in normal tissues, but it is strongly expressed in many carcinoma, its expression upregulation indicates shorten life span and poor prognosis of patients with tumor, therefore midkine maybe utilized as a tumor marker. Apply new molecular biology technology midkine is a candidate molecular target for gene therapy.
出处
《医学综述》
2007年第5期348-350,共3页
Medical Recapitulate
