期刊文献+

Alpha B-crystallin基因在人胶质瘤中的表达

Expression of Alpha B-crystallin gene in human glioma
暂未订购
导出
摘要 目的:探讨alpha B-crystallin基因在人胶质瘤中的表达水平。方法:采用RT-PCR方法检测人胶质瘤中alpha B-crystallinmRNA表达情况。结果:不同病理级别人脑胶质瘤组织中alpha B-crystallinmRNA表达均有不同程度下降。结论:Alpha B-crystallin基因表达下调可能与人胶质瘤的发生发展有关。 Objective :To study the expression and significance of alpha B-crystallin gene in human glioma. Method:Detecting the alpha B-crystallin mRNA expression by RT-PCR. Result:The expression of alpha B-crystallin mRNA was different in different degree of glioma. Conclusion: Downregnlation of alpha B-crystallin mRNA may he concerned with the development of human glioma.
作者 胡文忠
出处 《交通医学》 2007年第1期20-21,共2页 Medical Journal of Communications
关键词 α B-晶状体蛋白 RT—PCR 胶质瘤 Alpha B-crystallin RT-PCR glioma
  • 相关文献

参考文献8

  • 1Clark JI,P.J.Muchowski,Small heat-shock proteins and their potential role in human disease[J].Curr Opin Struct Biol,2000,10(1):52-59.
  • 2Mao,Y.W.,J.P.Liu,H.Xiang,et al.Human alphaA-and alphaB-crystallins bind to Bax and Bcl-X (S) to sequester their translocation during staurosporine-induced apoptosis[J].Cell Death Differ,2004,11(5):512-526.
  • 3Kerr,J.F.,C.Winterford,and B.Harmon,Apoptosis.Its significance in cancer and cancer therapy[J].Cancer,1994,73(8):2013-2026.
  • 4Oltvai,Z.,C.Milliman,and S.Korsmeyer,Bcl-2 heterodimerizes in vivo with a conserved homolog,Bax,that accelerates programmed cell death[J].Cell,1993,74 (4):609-619.
  • 5Kamradt,M.C.,F.Chen,and V.L.Cryns,The small heat shock protein alpha B-crystallin negatively regulates cytochrome c-and caspase-8-dependent activation of caspase-3 by inhibiting its autoproteolytic maturation[J].J Biol Chem,2001,276(19):16059-16063.
  • 6陈义军,章翔,费舟,顾建文,刘卫平.人脑胶质瘤凋亡的原位研究[J].第四军医大学学报,2000,21(9):1144-1146. 被引量:3
  • 7Oliver,B.and W.Michael.Apoptosis in gliomas,and its role in their current and future treatment[J].Front Biosci,2002(7):339-353.
  • 8Bardia,A.and C.W.T,Apoptosis in glioma cells:review and analysis of techniques used for study with focus on the laser scanning cytometer[J].J Neurooncol,2003,63(2):129-145.

二级参考文献7

  • 1[1]Kerr JFR,Winterford CM,Harmon BV.Apoptosis:Its significance in cancer and caner therapy[J].Cancer,1994(8);73:2013-2026.
  • 2[2]Oltvai ZN,Milliman CL,Korsmeyer SJ.Bcl-2 heterodimerizes in vivo with a conserved homolog,Bax,that accelerates programmed cell death[J].Cell,1993;74(4):609-619.
  • 3[3]Mainwaring PN,Ellis PA,Detre S et al.Comparison of in situ methods to assess DNA cleavage in apoptotic cells in patients with breast cancer[J].J Clin Pathol,1998;51(1):34-37.
  • 4[4]Heesters MA,Koudstaal J,Go KG et al.Analysis of proliferation and apoptosis in brain gliomas:Prognostic and clinical value[J].J Neurooncol,1999;44(3):255-266.
  • 5[5]Nishimura R,Nagao K,Miyayama H et al.Apoptosis in breast cancer and its relationship to clinicopathological characteristics and prognosis[J].J Surg Oncol,1999;71(4):226-234.
  • 6[6]Watanabe I,Toyoda M,Okuda J et al.Detection of apoptotic cells in human colorectal cancer by two different in situ methods:Antibody against single-stranded DNA and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling (TUNEL) methods[J].Jpn J Cancer Res,1999;90(2):188-193.
  • 7[7]Ikeda M,Shomori K,Endo K et al.Frequent occurrence of apoptosis is an early event in the oncogenesis of human gastric carcinoma[J].Virchows Arch,1998;432(1):43-47.

共引文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部