摘要
目的:研究白细胞介素-6(IL-6)基因启动子MbiI多态性在子宫内膜异位症、子宫肌瘤患者及正常人中的分布。方法:应用聚合酶链反应-限制性片段长度多态性技术检测98名子宫内膜异位症患者与97名子宫肌瘤患者及99名健康成年女性的白细胞介素-6基因启动子MbiI多态性,比较三组白细胞介素-6基因型和等位基因的分布频率。结果:CC、CG和GG基因型在子宫内膜异位症患者中分别为55.10%、42.86%、2.04%;在子宫肌瘤患者中分别为71.13%、27.84%、1.03%;在健康成年女性中分别为70.71%、28.28%、1.01%。子宫内膜异位症组与子宫肌瘤组及健康成年女性组基因型的分布频率差异有显著性,而子宫肌瘤组与健康成年女性组无显著性差异。结论:白细胞介素-6基因启动子MbiI的多态性分布与子宫内膜异位症的发病具有一定程度的相关性,而与子宫肌瘤的发病无相关性。
Objective： To detect the distribution of interleukin -6gene promoter region Mbi I in patients with endometfiosis , patients with myoma of uterus and normal Controls. Methods： Interleukin - 6 gene promoter region Mbi I polymorphism was detected by polymerase chain reaction -restriction fragment length polymorphism in patients with endometriosis （n = 98 ） , patients with myoma of uterus （n =97） and normal controls （n =99） . Results： The frequencies of CC, CG and GG genotypes were 55.10%, 42. 86% and 2. 04% in patients with endometriosis, while 71.13%, 27. 84% and 1.03% in patients with myorna of uterus, and 70. 71%, 28. 28% and 1.01% in normal controls. A significant difference was seen in the distribution frequency of interleukin - 6 genotype between patients with endometriosis and patients with myoma of uterus, patients with endometriosis and normal controls. There was no signifieant difference in the distribution frequency of interleukin - 6 genotype between patients with myoma of uterus and normal controls. Condusion： The distribution frequency of interleukin - 6 genotype has something to do with morbility of endometriosis but have nothing to do with that of myoma of uterus.
出处
《中国妇幼保健》
CAS
北大核心
2007年第7期914-916,共3页
Maternal and Child Health Care of China
