摘要
用雄性ＳＤ大鼠制备四氯化碳肝损伤模型。预先给予绞股蓝总皂甙（每日２５００ｍｇ／ｋｇ，连续１０日）和有机锗（每日５００ｍｇ／ｋｇ，连续２５日）作为四氯化碳拮抗剂，观察其对肝损伤的保护作用。结果发现：血清生化学指标改变不明显，但病理切片显示，绞股蓝总皂甙和有机锗均可以明显减轻四氯化碳所致的肝脂变和肝坏死。而绞股蓝总皂甙的拮抗作用要优于有机锗，这可能与其对微粒体酶系有较强的抑制作用有关。
ale SD rat were used as model of liver injury in-duced by CCl_4. Before giving CCl_4, the animals weretreated orallly with gypensides(GPS)(every day2500mg/kg for 10 days)and 132￣Ge(every day 500mg/kg for 25 days), respectively. There were no remark-able changes in MDA, SOD, ALT and other indices inserum among the several experimental groups, but thepathologic result showed that GPS and 132￣Ge were ableto alleviate obviously the liver necrosis and fatty de-generation caused by carbon tetrachloride. The antag-onistic role of GPS appeared to be much better thanthat of 132￣Ge. It might relate to the stronger inhibitionof GPS on microsomal enzymes.
出处
《职业医学》
1996年第3期8-10,共3页
China Occupational Medicine
