摘要
人类8型疱疹病毒(human herpesvirus-8,HHV-8)又称卡波氏肉瘤相关疱疹病毒(Kaposi’s sarcoma-associated herpesvirus,KSHV),是一种新的肿瘤病毒,目前被认为是卡波氏肉瘤(Kaposi’s sarcoma,KS)致病因子,并且与primary effusion lymphoma(PEL)和multicentric Castleman’s disease(MCD)相关,近几年研究发现还与其它疾病相关。HHV-8不像EBv那样广泛存在,而是具有明显的地域民族特征。HHV-8属于DNA病毒,编码许多蛋白,包括潜伏感染相关蛋白,裂解感染相关蛋白和HHV-8特有基因表达蛋白,在KS发病中起到关键作用。但HHV-8导致相关疾病的确切机制还不明确,仍是目前研究的焦点。
Human herpesvirus-8 （HHV-8） also referred to as Kaposi＇ s sarcoma-associated herpes-virus （KSHV） ,is a novel tumor causing virus, which is thought to be the etiologic agent of KS, and also is associated with primary effusion lymphoma（PEL） and multicentric castleman＇ s disease（MCD） HHV-8 encodes a number of viral proteins, including the proteins associated with HHV-8 latent infection and lytic infection, and the proteins unique to HHV-8, which are critical players in the development of KS and HHV-8-associated diseases. The proteins encoded by HHV-8 and association between HHV-8 and KS were reviewed.
出处
《中国生物工程杂志》
CAS
CSCD
北大核心
2007年第3期110-114,共5页
China Biotechnology
基金
国际科技合作重点项目(2005DFA30780)
