摘要
目的综述分化抑制因子2(inhibitor of differentiation2,Id2)在骨骼肌再生中的作用研究进展。方法广泛查阅近年来Id2生物学特性及其在骨骼肌再生中的作用相关文献,并综合分析。结果Id2通过结合E蛋白形成异二聚体,阻止生肌调节因子(myogenic regulatory factors,MRFs)与E蛋白结合而抑制MRFs的转录活性,抑制骨骼肌细胞分化。结论Id2在骨骼肌再生中起着重要作用。
Objective To review researches of the role of inhibitor of differentiation 2（Id2） in skeletal muscle regeneration. Methods The latest original literature concerning Id2 and its role in skeletal muscle regeneration was extensively reviewed. Results Id2 could form heterodimers by combining with E protein to prevent myogenic regulatory factors （MRFs） forming heterodimers by combining with E protein, to inhibit the transcription activity of MRFs and differentiation of skeletal muscle cell. Conclusion Id2 plays an important role in skeletal muscle regeneration.
出处
《中国修复重建外科杂志》
CAS
CSCD
北大核心
2007年第3期307-310,共4页
Chinese Journal of Reparative and Reconstructive Surgery
基金
广州市科技攻关计划科技攻关重大项目(2004Z1-E0031)
关键词
分化抑制因子2
骨骼肌
再生
研究进展
Inhibitor of differentiation 2 Skeletal muscle Regeneration Research advance
