摘要
目的通过检测累及三脑室底部颅咽管瘤组织中白细胞共同抗原CD45和细胞间粘附分子(ICAM-1)的表达来分析肿瘤组织与下丘脑的生长关系。方法采用免疫组化SP法检测CD45及ICAM-1蛋白在30例累及三脑室底部颅咽管瘤组织中的表达。结果CD45标记的炎症反应在累及三脑室底部的颅咽管瘤组织广泛存在,ICAM-1主要在肿瘤内层细胞及间质细胞表达,向三脑室底部生长的肿瘤基底层细胞无阳性表达。CD45及ICAM-1的阳性表达在不同病理类型的颅咽管瘤有明显差异,造釉细胞型颅咽管瘤的表达显著高于鳞状乳头型颅咽管瘤(P<0.05)。结论累及三脑室底部颅咽管瘤与下丘脑间主要为炎症粘连而非侵袭性生长,不同病理类型颅咽管瘤炎症差异可能影响其预后。
Objective To investigate the growth of craniopharyngioma involving the third ventricular floor with regad to the hypothalamus by detecting expressions of leukocyte common antigen （CD45） and intercellular adhesion molecule （ICAM-1） in the tumor tissue. Methods The expressions of CD45 and ICAM-1 proteins in 30 craniopharyngioma samples with third ventricular floor involvement were detected by SP immunohistochemisuy. Results The inflammations labeled by CD45 were identified commonly in the craniopharyngioma tissues involving the third ventricular floor. The expression of ICAM-I was mainly in the inner tumor cells and interstitial cells, but not detected in the basilar tumor cells growing toward the third ventricular floor. Adamantinomatons craniopharyngiomas showed markedly higher CD45 and ICAM-I expressions than squamous papillary tumors （P〈0.05）. Conclusion Inflammatory adhesion largely characterizes the growth of the craniopharyngioma tissues involving the third ventricular floor toward the hypothalamus without the tendency of invasion. The difference in the inflammation between the two types of craniopharyngioma may affect the prognosis of the patients.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2007年第3期377-379,共3页
Journal of Southern Medical University
关键词
颅咽管瘤
三脑室底部
下丘脑
CD45
细胞间粘附分子
craniopharyngioma
third ventricular floor
hypothalamus
CD45
intercellular adhesion molecule
