摘要
目的探讨双重滤过血浆置换治疗难治性重症肌无力的起效时间、临床疗效、并发症的防止及应用价值。方法31例难治性重症肌无力全部采用双重滤过血浆置换法,3d置换1次。置换液为20%白蛋白50ml、706代血浆1000ml。置换当日及置换后3、7、14d根据临床绝对记分法评分,评分当日清晨抽血查AchR-Ab。结果痊愈、基本痊愈、好转、显效和无效分别为2、4、11、17和3例,总有效率91.9%。有2例、2次在置换中出现低血压,对症处理后好转。结论双重滤过血浆置换能迅速降低血液中AchR-Ab水平,起效快、并发症少,对治疗难治性重症肌无力具有重要价值。
Objective To assess the therapeutic effect, timing of administration, complication prevention and management of the double filtration plasmapheresis （DFP） in the treatment of refractory myasthenia gravis （MG）. Methods Thirty-one patients with refractory MG were treated with KM 8800 membrane, plasmapheresis monitor. DFP was performed every 3 days and the exchanging liquid was composed of 50 ml of 20% albumen and 1000 ml plasma substitute. Physical examination for absolute clinical score and blood sample was collected for AchR-Ab determination early in the morning on days 0, 3, 7, 14 of DFP. Results With a total effective rate of 91.9%, complete recovery, basic recovery, improvement, and response was achieved in 2, 4, 11, and 17 patients, respectively, whereas the other 3 failed to respond. Hypotension occurred twice in 2 cases and was corrected after symptomatic treatment. Condusion DFP may effectively lower blood AchR-Ab level of with minimal complications, and can be valuable for treatment of refractory MG.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2007年第3期355-357,共3页
Journal of Southern Medical University
关键词
难治性重症肌无力
双重滤过血浆置换
乙酰胆碱受体抗体
refractory myasthenia gravis
double filtration plasmapheresis
acetylcholine zeceptor antibody
