摘要
目的探讨滤泡树突细胞肉瘤的临床病理特征、诊断和鉴别诊断。方法对1例肠系膜淋巴结滤泡树突细胞肉瘤进行光镜和免疫组化观察,结合文献进行讨论。结果镜下肿瘤由旋涡状、束状排列的胖梭形、卵圆形或多边形瘤细胞和大量混杂的淋巴细胞组成。免疫表型瘤细胞表达CD35和CD23,弱阳性表达CD68、S-100和EMA;淋巴细胞表达CD45RO和CD3。结论淋巴结滤泡树突状细胞肉瘤是一种罕见的免疫辅助细胞中度恶性肿瘤,其诊断依靠组织病理学和免疫组化,治疗以手术切除为主,必要时辅以化疗和(或)放疗。
Objective： To study the clinicopathologic features, diagnosis and differential diagnosis of follicular dendritic cell sarcoma（FDCS）. Methods One case of FDCS in the small intestinal mesentery was examined by light microscopy and immunohistochemistry. Results： Microscopically,the tumor displayed a characteristic biphasic pattern which was composed of plump spindle - shaped, ovoid or polygonal neoplastic cells that arranged in concentric whorls and abundant intermixed small lymphocytes. Immunochemistry type： The neoplastic cells were positive for CD35 ＆ CD23 ,weakly positive for CD68 , S - 100 protein ＆ EMA, lymphocytes showed a T cell phenotype （ CD45RO and CD3^＋ ）. Conclusion： Follicular dendritic cell sarcoma is an extremely rare disease of the accessory immune cells which should be viewed as a tumor of intermediate malignancy and treated by complete excision with adjuvant chemotherapy or radiotherapy if necessary.
出处
《现代肿瘤医学》
CAS
2007年第3期404-407,共4页
Journal of Modern Oncology
关键词
肠系膜肿瘤
滤泡树突细胞肿瘤
免疫组化
诊断
small intestinal mesentery neoplasms
follicular dendritic cell sarcoma
immunohistochemistry
diagnosis
