摘要
目的探讨细胞周期调控因子cyclinB1、p34cdc2在卵巢肿瘤发生、发展及预后中的作用。方法应用免疫组化SP法对正常卵巢、卵巢良性上皮性肿瘤及恶性肿瘤中cyclinB1、p34cdc2的表达进行检测。结果cy-clinB1和p34cdc2在正常卵巢、良性肿瘤和恶性肿瘤中的阳性表达呈递增趋势,在恶性肿瘤的阳性表达率显著高于正常卵巢和良性肿瘤(P<0.05);并且cyclinB1和p34cdc2的表达与肿瘤的分化程度、临床分期及预后明显相关(P<0.05)。结论cyclinB1和p34cdc2在卵巢肿瘤的进展、诊断和判断预后方面有一定的意义。
Objective： To study the role of cyclinBl and p34^cdc2 in epithelial ovarian tumor. Methods： Immunohistochemistry was used to examine the expression of eyelinB1 and p34^cdc2 in normal ovay, benign epithelial ovarian tumor and malignante ovarian tumor. Results： The expression of eyelinB1 and p34^cdc2 increased with normal ovay, benign epithelial ovarian tumor and malignante tumor,the expression rate in malignancy was remarkable higher than in normal ovay and benign epithelial ovarian tumor（P 〈 0.05） ;and significant correlation was found in the positive expression of eyclinB1 and p34^cdc2 in grading, staging and prognosis （P 〈 0.05 ）. Conclusion： The expression of eyelinB1 and p34^cdc2 is positively correlated with development and prognosis of ovarian tumor.
出处
《现代肿瘤医学》
CAS
2007年第3期394-395,共2页
Journal of Modern Oncology
