摘要
目的探讨手术结合新辅助化疗治疗局限期小细胞肺癌的临床疗效及化疗和手术的相互影响。方法回顾性总结367例局限期小细胞肺癌临床资料,比较不同方法的疗效,评价化疗的毒性反应及对术后并发症发生的影响。结果根治性手术术前开始化疗组和术后开始化疗组1、3、5年存活率分别为87.5%、57.8%、49.6%和86.8%、47.4%、34.2%,二组间1年存活率无显著差异(P>0.05),3、5年的存活率差异显著(P<0.05);姑息性手术组1、3存活率低,无5年存活者;围手术期死亡2例(0.5%),术后并发症69例(18.6%);术前化疗期间无死亡病例,术后化疗死亡2例。结论根治性手术结合术前、术后化疗治疗局限期小细胞肺癌可获得满意的临床效果,化疗不增加手术危险性,术后1月开始化疗是安全的。
Objective： To explore the clinical outcomes of surgical treatment combining with neo - adjuvant chemotherapy on the patients with limited stage small cell lung cancer, and the relationship between surgical treatment and chemotherapy. Methods： To analyze the clinical data of 367 patients with limited stage small cell lung cancer, to compare the clinical outcomes of different methods on treating limited stage small cell lung cancer patients, and to evaluate the side effects of chemotherapy and its influences on operation. Results ： The 1, 3, 5 year survival rates in patients with limited stage small cell lung cancer whom taken radical excision and pre - and post - operation chemotherapy or post - operation chemotherapy only were 87.5% , 57.8%, 49.6% and 86.8% , 47.4% ,34.2% respectively. There were significant differences between the two groups in 3, 5 year survival rates but not in 1 year survival rate. The 1, 3 year survival rates in patients performed palliative excision were very low, and no 5 year survival was found. There were 2 death during perioperative period, and 69 （ 18.6% ） perioperative incidents. No death in pre - operation chemotherapy, but 2 in post-operation chemotherapy. Conclusion： Radical excision combining with pre - and post - operation neo - adjuvant chemotherapy is fight choice for patients with limited stage small cell lung cancer. There are no more risks for patients whom performed pre - operation chemotherapy, and it is safe to start chemotherapy 1 month post-operation.
出处
《现代肿瘤医学》
CAS
2007年第3期350-352,共3页
Journal of Modern Oncology
关键词
小细胞肺癌
外科手术
新辅助化疗
small cell lung cancer
surgery
neo - adjuvant chemotherapy
