摘要
ＳＤ大鼠分别用５ｍｇ／ｍ３和５０ｍｇ／ｍ３ＣＳ２吸入染毒６个月。结果表明：５０ｍｇ／ｍ３ＣＳ２接触组肝铜含量显著减少（Ｐ＜０．０５），血浆ＬＣＡＴ活性显著抑制（Ｐ＜０．０１）。肝铜含量与血浆ＬＣＡＴ活性呈正线性相关（Ｐ＜０．０１）。实验结果提示：ＣＳ２能引起铜代谢紊乱，降低体内铜水平；血浆ＬＣＡＴ是一种铜酶；ＣＳ２可通过干扰铜代谢，从而抑制ＬＣＡＴ活性，引起脂质代谢紊乱。
prague Dawley rats had inhaled CS 2 vapours 5 hours a day,6 days a week for six months The CS 2 concentrations were 5mg/m 3 and 50mg/m 3 respectively The results showed that the level of liver copper was significantly decreased( P <0 05) and the plasma LCAT activity was significantly inhibited( P <0 01) in the group having exposed to 50mg/m 3 CS 2 vapour for six months A significant positive linear correlation existed between the plasma LCAT activities and liver copper values( P <0 01) The conclusions might be as follow:Exposure to CS 2 could result in disturbances of copper metabolism LCAT,as a kind of copper metalloenzymes,could be inhibited by CS 2 through interfering copper metabolism and result in the disturbances of lipid metabolism
出处
《职业医学》
1996年第5期4-5,共2页
China Occupational Medicine
