摘要
目的:测定帕珠沙星对社区获得性感染(CAI)常见致病菌PK/PD,为临床制定合理给药方案提供参考依据。方法:依GCP要求,进行健康成年志愿者药代动力学试验,以HPLC法测定血浆药物浓度,采用3P97软件计算药代动力学参数;以平板二倍稀释法测定MIC,计算AUIC(AUC0-24/MIC)、Cmax/MIC。结果:帕珠沙星对肺炎链球菌的AUIC>25和Cmax/MIC>8的比例均为66.7%;大肠埃希菌属和肺炎克雷伯菌属的Cmax/MIC>8分别为71.4%和76.5%,而对铜绿假单胞菌属、肠杆菌属、嗜血杆菌属在82.4～90%之间,变形杆菌属及其他革兰阴性菌的Cmax/MIC>8超过90%;AUIC>100的比例与之相似。结论:帕珠沙星对CAI常见致病菌有较好的临床杀菌活性。
Objective：To study PK/PD of pazufloxacin against pathogen of community acquired infection（CAI）.Methods：According to GCP, we have achieved pharmacokinetics trial in Chinese adult; the concentration of pazufloxacin in plasma was determined by HPLC; the pharmacokinetics parameters were estimated by 3P97; MICs were determined by standard plate dilution method, then the AUIC（AUC0-24/MIC） and Cmax/MIC were estimated,Results：For streptococcus pneumoniae , the ratio of AUIC〉25 and Cmax/ MIC〉8 was 66.7% . In G- bacillus, the ratio of Cmax/MIC〉8 was 71.4% and 76.5% against E. coli and K. Pneumoniae ,and it was 82.4-90% against P. aeruginosa, Cedecea and Hemophilus ,while it was over 90% against Proteus and other G- bacteria ,which were over AUIC〉100,Conclusion：Pazufloxacin may have powerful bactericidal activity against pathogen from CAI.
出处
《中国药物应用与监测》
CAS
2007年第1期32-35,共4页
Chinese Journal of Drug Application and Monitoring
