摘要
采用气相色谱/傅立叶红外光谱和气相色谱/质谱仪分析大鼠肝脏中单甲脒的代谢产物.证明大鼠经口摄入单甲脒后,在肝脏中迅速代谢,其代谢中间产物为2,4-二甲基苯胺和含酰胺基的化合物.
N'-(2,4-dimethylphenyl)-N-methyIformamidine is a new type of organic-nitrogen insecticide and miticide. GC/FTIR and GC/MS was applied to analyse the metabolites of N'-(2, 4-dimethylphenyl)-N-methylformamidine in rat's livers. After N'-(2, 4-dime-thylphenyl)-N-methylformamidine was administered orally to rats, it was metabolized rapidly in the liver. The middle metabolites were 2,4-dimethylbenzenamine and the compounds with radical of -CONH2.
出处
《环境化学》
CAS
CSCD
北大核心
1996年第6期547-551,共5页
Environmental Chemistry
基金
国家自然科学基金
关键词
农药
单甲脒
二甲基苯胺
大鼠
气相色谱
pesticide, N'-(2,4-dimethylphenyl) -N-methylformamidine, 2,4-dime-thylbenzenamine, metabolism, rat.
