摘要
空腹血糖受损(IFG)是糖尿病及心血管疾病发病的危险因素,IFG的早期诊断对于糖尿病和心血管疾病的防治十分重要,确立IFG的诊断标准更是影响深远。但目前ADA与WHO对于IFG的诊断标准尚存在分歧。2003年11月ADA提出将IFG诊断标准下限下调为5.6mmol/L,但WHO经过讨论后认为基于证据不充分、缺乏硬性终点事件的相关研究、增加社会负担等原因,应保持原诊断标准6.1mmol/L不变。因此国内外大量的实验研究从各个方面对诊断标准的确立进行了论证,开展了全球性的探讨,以期能尽早制定出兼具敏感性和特异性的诊断标准用以指导临床工作。
Impaired fasting glucose （IFG）, associated with impaired insulin secretion and impaired suppression of hepatic glucose output, is a risk factor for future diabetes, cardiovascular diseases and adverse outcomes. It is important to diagnose and prevent IFG at the early stage. However, the criterion of IFG remains ambiguous. In November 2003, American Diabetes Association （ADA） revised the lower cut-point of IFG to 5.6mmol/L, however, WHO still recommended 6. 1mmol/1 as the fasting plasma glucose cut-point for IFG for some reasons, such as deficient evidence of any benefit in terms of reducing adverse outcomes or progression to diabetes and the loading impacts on individuals and health systems. Various approaches and researches for deriving a specific cut-point for defining IFG have been performed to provide the evidences for the criterion for IFG in national and international.
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2007年第2期125-128,共4页
Chinese Journal of Diabetes
关键词
空腹血糖受损
参考值
心血管疾病
糖尿病
Impaired fasting glucose
Reference values
Cardiovascular diseases
Diabetes mellitus
