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表皮生长因子受体家族与口腔肿瘤

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摘要 表皮生长因子受体(EGFR,ErbB)家族在特异性配体的诱导下能够发生家族成员的二聚化,从而激活细胞内下游信号转导途径,调控细胞的增殖、分化、迁移等生物效应。异常的ErbB受体信号与口腔肿瘤的发生发展有着密切的关系。其在多种口腔肿瘤中表达或高表达,可作为评估和判断口腔鳞癌细胞增殖状态、恶性度及患者预后的参考指标。以ErbB受体为靶点的抗肿瘤药物成为近年来口腔肿瘤治疗研究中的热点领域。
作者 薛浩伟 张令达
机构地区 安徽医科大学第一附属医院口腔颌面外科
出处 《广东牙病防治》 2007年第3期131-133,共3页 Journal of Dental Prevention and Treatment
关键词 表皮生长因子受体 口腔肿瘤 鳞癌
分类号 R737.33 [医药卫生—肿瘤]
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参考文献27

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二级参考文献14

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广东牙病防治
2007年 第3期

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