摘要
目的探讨原发性肾病综合征患儿(PNS)血脂代谢紊乱与肾功能改变的关系。方法2004-01—2006-01,根据肾功能检查结果,将广西医科大学第一附属医院儿科收治的76例PNS患儿分成无肾功能损害组(46例)与肾功能损害组(30例),检测血浆总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、非-高密度脂蛋白(non-HDL)、低密度脂蛋白(LDL)、载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)、ApoA1/B、血浆尿素氮(BUN)、肌酐清除率(Ccr)和尿酸(UA)等指标。结果(1)肾功能损害组TG、BUN、Ccr和UA均明显高于无肾功能损害组;(2)76例PNS患儿TG与Ccr及UA呈高度正相关(P<0.01),ApoA1与Ccr呈中度正相关(P<0.05),ApoB与UA呈中度正相关(P<0.05);(3)76例PNS患儿non-HDL与LDL呈高度正相关(P<0.01)。结论PNS合并肾功能损害的血脂代谢紊乱以TG显著增高为特征;TG和non-HDL变化可以作为临床判断PNS患儿肾功能损害程度及调脂措施有效性的指标。
Objective To probe into the relationship between dyslipidemia and the alternation of renal funetion in children with primary nephritic syndrome（PNS）. Methods Totally 76 children with PNS were divided into two groups,the non-renal inadequacy group（46 children） and the renal inadequacy group（ 30 children）, according to renal function. Total cholesterol （ TC ）, triglyeeride （ TG ）, high density lipoprotein （ HDL ）, non-HDL, low density lipoprotein （ LDL ）, apolipoprorein A 1 （ ApoA1 ）, apolipoprotein B （ ApoB ）, ApoAl/B, blood urea nitrogen （ BUN ）, ereatinine clearance rate （ Cer ） and uric acid（ UA ） in plasma were deteeted. Results （ 1 ） TG, BUN,Cer and UA in the renal inadequaey group signifieantly inereased eompared with the non-renal inadequaey group. （2） There was outstanding positive eorrelation between TG and Cer,UA（ P 〈0.01） ,medium positive correlation between ApoA1 and Cer（ P 〈0. 05） ,medium positive eorrelation between ApoB and UA（ P 〈 0. 05 ） in 76 PNS ehildren. （ 3 ） Outstanding positive eorrelation was observed between non- HDL and TG（ P 〈 0.01 ） in 76 PNS children. Conclusion Significantly inereased TG is the feature of dyslipidemia in PNS ehildren eomplieating renal inadequacy. It is favorable identifieation for TG, non-HDL to judge the degree of renal inadequaey and the effieaey of therapy in elinie.
出处
《中国实用儿科杂志》
CSCD
北大核心
2007年第2期121-123,共3页
Chinese Journal of Practical Pediatrics
关键词
肾病综合征
高脂血症
肾功能
儿童
Nephritie syndrome
Hyperlipidemia
Renal function
Children
