摘要
目的探讨肾病综合征激素抵抗患者肾脏组织中GRβ和GRα的表达及意义。方法据糖皮质激素治疗效果将原发性肾病综合征患者分为以下3组:激素敏感组、激素抵抗组、复发后抵抗组。用免疫组织化学方法检测45例原发性肾病综合征患者肾组织中GRβ和GRα的表达,并用计算机图像分析系统对结果进行分析。结果复发后激素抵抗组和激素抵抗组肾组织中GRβ含量明显高于激素敏感组(P<0.05);复发后激素抵抗组肾组织中GRβ与激素抵抗组之间差异无统计学意义(P>0.05);复发后激素抵抗组和激素抵抗组肾组织中GRα含量明显低于激素敏感组(P<0.05);复发后激素抵抗组肾组织中GRα与激素抵抗组之间差异无统计学意义(P>0.05)。结论肾组织中GRβ的升高和GRα降低可能与原发性肾病综合征激素抵抗有关;检测肾组织中GRβ和GRα表达变化有助于预判断预后和调整治疗。
Objective To investigate the role of GRα and GRβ in the occurrence of steroid resistant nephrotic syndrome. Methods The 45 patients were devided into 3 groups （steroid sensitive group, steroid resistant group and recurrent steroid resistant group） according to the response to the treatment with corticosteroids. The expression of GRα and GRβ in renal tissues were tested by means of immunohistochemistry technique in 45 NS patients before treatment with corticosteroids. Results The expression of GRα and GRβ in renal tissues increased markedly in the groups of steroid resistant and recurrent steroid resistant nephrotic syndrome groups compared with the steroid sensitive group. There was no significant difference of expression of GRα and GRβ in renal between steroid resistant group and recurrent steroid resistant group. The level of GRα and GRβ of recurrent group was significant higher than that before the recurrence. Conclusion The increase of GRα and GRβ level might related with the steroid resistant in nephrotic syndrome,although it is uncertain that the change might be cause or the result. But the analysis of serum GRα and GRβ might be beneficial to predict the occurrence of steroid resistance in nephritic syndrome.
出处
《重庆医学》
CAS
CSCD
2007年第5期406-408,共3页
Chongqing medicine
关键词
肾病综合征
糖皮质激素受体Β
糖皮质激素受体Α
激素抵抗
nephrotic syndrome
glucocorticoid receptor β
glucocorticoid receptor α
glucocorticoid resistant
