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细胞色素P4501A1基因多态性及其与肿瘤易感性研究进展 被引量：3

Advances of Cytochrome P4501A1 Gene Polymorphisms and the Susceptibility of Tumour
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摘要 细胞色素P450（Cytochrome P，CYP）1A1是一种重要的P450系氧化代谢酶，广泛分布于肝外组织，催化多种前致癌物的活化并且在雌激素代谢中起作用。目前发现4个重要的多态性位点，即3801 T→C、4889A→G、3205T→C、2453C→A，CYP1Al基因多态性与多种肿瘤的易感性相关。 Cytochrome P450 （CYP）1A1 is an important metabolic oxidase of P450 family. It distributes widely in extrahepatie tissues. CYP1A1 catalyzes the metabolic activation of proeareinogens and plays an important role in estrogen metabolism. Up to date, four polymorphisms have been identified,they are 3801 T→C , 4889A→G,3205T→C and 2453C→A. Those CYP1A1 gene polymorphisms may related to the susceptibility genes of various tumors.
作者 刘春莲 焦海燕
机构地区 宁夏医学院医学遗传学与细胞生物学教研室
出处 《国际遗传学杂志》 CAS 2007年第1期52-56,共5页 International Journal of Genetics
基金 宁夏回族自治区自然科学基金（No.NZ0535）
关键词 细胞色素P4501A1 基因多态性 肿瘤易感性 Cytochorme P450 1A1 Gene polymorphism Tumor susceptibility
分类号 R730 [医药卫生—肿瘤]
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二级参考文献32

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共引文献64

同被引文献26

  • 1燕贞,吴拥军,吴逸明.细胞色素P450 2D6与吸烟所致肺癌易感性的关系研究[J].卫生研究,2007,36(1):112-113. 被引量：4
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  • 3燕贞,吴拥军,吴逸明.CYP2D6 C188T单核苷酸多态与肺癌易感性[J].环境与职业医学,2007,24(2):167-169. 被引量：5
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国际遗传学杂志
2007年 第1期

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