摘要
目的观察2型糖尿病患者血糖控制前后对部分骨代谢指标、胰岛素样生长因子-1(IGF-1)及骨密度的影响。方法(1)选择36例2型糖尿病患者,年龄43-65岁,其空腹血糖及餐后血糖均符合WHO的糖尿病诊断标准,HbA1c升高,抽取空腹血,提取血清,放于-70℃冰箱中保存,同一天留取尿测尿1型胶原氨基末端肽(NTX),然后应用胰岛素或口服降糖药联合胰岛素使空腹血糖控制在6-7mmol/L,餐后2小时血糖控制在7-8mmol/L,HbA1c正常,并维持治疗1年后再抽取空腹血,提取血清,同一天留取尿检测相关指标。(2)治疗前后采用双能X线骨密度仪测量腰椎、股骨颈及Wards三角的骨密度。应用ELISA法测定血清IGF-1及尿NTX,骨钙素(BGP)采用放免法测定,批内变异系数(CV)<4%。结果治疗后腰椎、股骨颈、Wards三角骨密度明显高于治疗前,BGP、IGF-1水平高于治疗前,NTX低于治疗前,差异有显著性意义。结论血糖的良好控制可提高2型糖尿病患者的骨密度,提高BGP、IGF-1水平,降低NTX水平。
[Abstract] Objective To Observe the influence of partially bone metabolic index, insulin shape growth factor- 1 （ IGF-1 ） and bone density for2 type diabetic controls blood sugar before and after . Methods （1）Select 36 examples of 2 type diabetics , age 43--65 year,all Value of empty stomach blood sugar and the blood sugar after eating accords with the diabetes diagnosis standard of WHO, HbAlc goes up , Draw empty stomach blood, put in --70 ℃refrigerator in preservation, same day reserve urine to measure NTX , then apply insulin or take orally to reduce sugar medicine joint insulin make the blood sugar in 6-7 mmol/L, the blood sugar after eating in 2 hours in 7-8 mmol/L, HbAlc notmal,and after main- taining treatment 1 years take out again empty stomach blood, draw serum , is same to reserve one day to take urine detection related index. （2）Treatment before and after adopt double energies X line bone density instrument measure lumbar vertedra and collum femoris and the bone density of Wards triangle. Apply ELISA measure serum IGF-1 and NTX and BGP , in batch coefficient of variation （CV）〈4%. Results After treating lumbar vertedra and Collum femoris , Wards triangle bone density is higher than treatment before obviously,The level of BGP and IGF-1 are higher than those of treatment,the level of NTX is lower than that of treatment , Their discrepancy has apparently statistics meaning. Conclusions Good control blood sugar can raise the bone density of 2 type diabetics , raises the level of BGP and IGF-1 , and reduces the level of NTX.
出处
《青岛医药卫生》
2007年第1期7-9,共3页
Qingdao Medical Journal
