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N-取代乙醇胺对4-氟-1-酰基苯的选择性胺化反应 被引量：1

Selective Amination of 4-Fluoro-1-acylbenzenes Using N-Substituted Ethanolamine
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摘要 研究了4-氟-1-酰基苯和N-取代乙醇胺在酰胺类溶剂或不加溶剂中反应,在不需要金属催化剂和另外加碱的条件下选择性地得到胺化产物,实验操作简单,符合SNAr取代机理.一系列羟乙基胺基酰基苯产物均经过元素分析(HRMS),IR,MS和NMR的测定. A selective and simple amination of 4-fluoro-1-acylbenzenes was achieved by using N-substituted ethanolamine neatly or in amidated solvent. The procedure in the absence of metal catalysts and additional bases was carried out throughout SNAr substitution mechanism. A series of 4-[N-alkyl-N- （2-hydroxylethyl）]amino-1-acylbenzene products were characterized by elemental analysis （HRMS）, IR, MS and NMR spectra.
作者 戴春亚 蔡良珍 赵韧 陶晓春
机构地区 华东理工大学应用化学研究所
出处 《有机化学》 SCIE CAS CSCD 北大核心 2007年第1期116-119,共4页 Chinese Journal of Organic Chemistry
关键词 4-氟-1-酰基苯 N-取代乙醇胺 胺化反应 4-fluoro-l-acylbenzene N-substituted ethanolamine amination
分类号 O621.25 [理学—有机化学]
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参考文献13

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同被引文献15

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有机化学
2007年 第1期

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