摘要
目的评价环孢素与甲氨蝶呤分别治疗对糖皮质激素不敏感的中度支气管哮喘的临床疗效。方法25例中度支气管哮喘患者，分为A、B两组：A组15例，应用甲氨蝶呤，每周10mg，po，qd；B组10例，应用环孢素3mg·kg^-1·d^-1，po，qd。共3个疗程：第1个疗程12周，其后每间隔4-6周，再行第2，3个疗程治疗（每次4周）。观察临床疗效及肺功能变化。结果A组和B组总有效率分别为73．3％，90．0％（P〈0．05）。B组肺功能指标（FEV1％）明显改善（P〈0．01）。结论小剂量环孢素治疗中度支气管哮喘疗效优于甲氨蝶呤，且使用方便，疗效好，未见明显不良反应，相对较安全。
Objective To compare the clinical effectiveness of cyclosorin （CsA） and methotrexate （MTX） in treating moderate asthma which is insensitive to glucocorticoids. Methods Twenty-five patients with moderate asthma were randomly divided into two groups ： the patients in the group A received CsA treatment, with 3 mg·kg^-1·d^-1 of CsA orally, while in group B, with MTX treatment,10 mg of MTX orally, once a week. Both treatments persisted 12 weeks as the first period. After an interval of 4-6 weeks, another treatment period began. Then the clinical effectiveness and pulmonary functional change were observed when three treatment periods were finished. Results CsA showed a better clinical results and pulmonary functional index （FEV1%） in group A than in group B. Conclusion Low dose of CsA in treating moderate asthma exhibits better effectiveness. It is convenient to manipulate and safer for patients with no prominent side-effects.
出处
《医药导报》
CAS
2007年第3期250-251,共2页
Herald of Medicine
关键词
环孢素
甲氨蝶呤
哮喘
Cycolosorin
Methotrexate
Asthma
