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真菌β-1,3-葡聚糖合酶——一种抗真菌药物的靶标 被引量：4

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摘要 真菌β-1,3-葡聚糖合酶(β-1,3-glucan synthase,GS)是由催化亚基和调节亚基组成的酶复合体。在酿酒酵母中GS的催化亚基是由2个序列高度相似的基因FKS1和FKS2编码的,在其他酵母中也存在多个与酿酒酵母FKS相似的基因,而在大多数丝状真菌中只存在1个FKS基因。文中主要介绍酿酒酵母和其他重要真菌中FKS基因的研究进展,对FKS基因的结构、在细胞中的定位、以及调控机制作了概括,并讨论了以真菌β-1,3-葡聚糖合酶为靶标开发新的抗真菌药物的研究现状和发展前景。
作者 陈婕 崔志峰
机构地区 浙江工业大学生物与环境工程学院
出处 《生命的化学》 CAS CSCD 北大核心 2007年第1期42-45,共4页 Chemistry of Life
基金 国家重点基础研究发展计划(973计划)资助项目(No.2003CB114400)
关键词 真菌细胞壁 β-1 3-葡聚糖合酶 FKS基因 抗真菌药物靶标
分类号 Q936 [生物学—微生物学]
  • 相关文献

参考文献14

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二级参考文献42

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共引文献9

同被引文献16

  • 1Soczo G,Kardos G,Varga I.In vitro study of candida tropicalis iso-lates exhibiting paradoxical growth in the presence of high concentra-tions of caspofungin. Antimicrobial Agents and Chemotherapy . 2007
  • 2Dijkgraaf G J.Mutations in Fkslp affect the cell wall content ofβ-1,3-andβ-1,6-glucan is Saccharomyces cerevisiae. Yeast . 2002
  • 3Stevens DA,Ichinomiya M,Koshi Y,et al.Escape of Candida from caspofungin inhibition at concentrations above the MIC(paradoxical effect)accomplished by increased cell wall chitin;evidence for beta-1,6-glucan synthesis inhibition by caspofungin. Antimicrobial Agents and Chemotherapy . 2006
  • 4Desnos-ollivier M,Bretagne S,Raoux D.Mutations in the fks1 genein Candida albicans,C.tropicalis,and C.krusei correlate with ele-vated caspofungin MICs uncovered in AM3 mediumusing the method ofthe European Committee on Antibiotic Susceptibility Testing. Anti-microbial Agents and Chemotherapy . 2008
  • 5Denning,DW.Echinocandin antifungal drugs. Lancet,The . 2003
  • 6冯贻安,崔志峰.真菌几丁质合酶的研究进展[J].微生物学通报,2008,35(2):267-271. 被引量：9
  • 7杨开,胡君荣,何荣军,张安强,吴学谦,孙培龙.食药用菌功能性β-葡聚糖荧光法测定研究[J].菌物学报,2009,28(3):399-406. 被引量：7
  • 8黄金伟,陈海泉,余方友,叶忠亮,陈丽芬,丁茂文,李国雄.侵袭性肺部真菌感染的诊疗情况分析[J].中华临床感染病杂志,2009,2(3):151-153. 被引量：4
  • 9曾荣,陈旭,李岷.树突细胞相关C型凝集素-1受体介导的抗白念珠菌免疫作用及机制[J].国际皮肤性病学杂志,2011,37(3):177-179. 被引量：2
  • 10郑楠薪,胡丹丹,姜远英,王彦.致病真菌几丁质合成调控的研究进展[J].第二军医大学学报,2014,35(5):549-554. 被引量：3

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二级引证文献8

生命的化学
2007年 第1期

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