摘要
目的:采用光纤化学传感技术实时、在位监测固体制剂体外溶出度的测定并与2000年版中国药典方法比较。方法:应用光纤原位药物溶出度/释放度试验仪,将分支光纤一端连接光源,公共端部探头浸入溶出液;另一端连接检测器,计算机记录并处理数据。结果:本法监测药物溶出的全过程,显示药物实时溶出曲线图,直接提取相关参数,与药典方法比较,无统计学差异(P>0.05)。结论:光纤化学溶出度过程监测法能够有效地测定固体药物的体外溶出度,并能真实地反映药物溶出的全过程。
Objective：To study a method which can monitor the dissolution rate of drug on - line -- fiber optic chemical sensor dissolution test （FOCSDT）. And compare the difference of this method with CHP（2000）. Method： By mean of FOCSDT, bifurcated optical fiber was used to connect light source and detector and the common end was dipped in the dissolution vessel. The dissolution procession could be monitored through computer. Result：This procession analysis could test the whole process of drug and get dissolution graph. The parameters obtained by FOCSDT had no significant difference compared with the method in ChP 2000 （P 〉 0. 05）. Conclution： This procession analysis can reflect the real dissolution of drug and obtain the total information.
出处
《药物分析杂志》
CAS
CSCD
北大核心
2007年第2期238-241,共4页
Chinese Journal of Pharmaceutical Analysis
基金
新疆维吾尔自治区高技术发展计划资助项目(200311110)
关键词
光纤溶出度/释放度过程监测法
药典溶出度测定方法
复方盐酸阿米洛利片
fiber optic chemical sensor dissolution test （FOCSDT）
ChP （2000） dissolution test
compound amiloride hydrochloride tablets
