摘要
目的了解低体重儿、早产儿败血症不同阶段感染菌株病原菌分布特点及耐药性。方法回顾性调查医院近3年间低体重儿、早产儿败血症血培养分离的病原菌菌株,结合出生后败血症的发作时间分组。结果970例低体重儿、早产儿可疑标本,细菌培养阳性率为17.5%;大多数败血症为出生3d后的晚期发作,占75.3%,迟发性败血症组主要病原菌为革兰阳性球菌,并以葡萄球菌属为主,占所有感染菌株的80.5%;早发性败血症组革兰阴性菌与革兰阳性菌感染比例大致相同,分别为47.6%和52.4%;并且迟发性败血症的耐药性明显高于早发败血症组。结论治疗新生儿感染的关键,是掌握新生儿不同时期感染病原菌的分布特点及药敏规律,根据药敏结果选用抗菌药物,避免滥用。
OBJECTIVE To understand the distribution of pathogen in very-low-birth-weight or preterm infants septicemia in early-onset and late-onset and drug sensitivity. METHODS Bacterial isolates from inpatients of verylow-birth-weight or preterm infants septicemia over a period of 3 years were retrospectively analyzed,and classified as when septicemia was happened. RESULTS The positive rate of isolates was 43.2% in 970 samples of very-lowbirth-weight or preterm infants septicemia. Most of the sepsis detected by blood culture was late-onset neonatal sepsis （58.6%）. Pathogen of late-onset neonatal sepsis mostly was Gram - positive cocci, Staphylococcus were found to be the most common isolates（80.5 %）. In early-onset sepsis group, the isolates rates of Gram-negative and Gram-positive bacteria were mostly in proportion, there were 52.4 % and 47.6 %, respeitively. The resistance rate of late-onset sepsis group was higher than that of early-onset one. CONCLUSIONS The key of curing infants septicemia is that we should master the distribution of pathogen of very-low-birth-weight or preterm infants septicemia in early-onset and late-onset and drug sensitivity. Antimicrobial therapy should be initiated under the guidance of anti-microbial sensitivity test, in order to avoid abuse of antimicrobial.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2007年第2期236-238,共3页
Chinese Journal of Nosocomiology
关键词
低体重儿
早产儿
败血症
病原菌
抗菌药物
耐药性
Very-low-birth-weight infants
Petrerm infants
Septicemia
Pathogen
Antibiotics
Drug resistance
