摘要
对硝普钠控制性降压前后犬血流动力学和Pa_(-ET)DCO_2变化同时作了观察,结果全程肺内分流率及肺泡死腔量比均不变(P>0.05)。降压30%45分内对照组PaCO_2、P_(ET)CO_2上升,而降压组呈下降趋势,降压停止后回升。降压前、中、后PaCO_2与P_(ET)CO_2均紧密相关,Pa_(-ET)DCO_2稳定在0.65～1.0kPa(4.9～7.5mmHg,P>0.05)。提示硝普钠控制性降压时P_(ET)CO_2与PaCO_2吻合良好,无创连续监测呼气末CO_2分压仍能准确评估PaCO_2。
This experimental study was to investigate the effect of sodium nitroprusside (SNP)-in-duced hypotensin on the difference between arterial and end-tidal CO_2 tension (P_(a-ET)CO_2). Seventeen adult mongrel dogs undergoing procaine balanced anesthesia, were randomly allocated to receiving intravenous infusion of normal saline as control(group A)or SNP (group B). MAP was decreased by 30%. Heart rate kept stable in control group,however there were significant tachycardia and rebound hypertension in group B. The values of right-to-left shunt ratio (Q_s/Q_T) and alveolar deadspace to tidal volume ratio didn't change (P>0.05) in both groups. In group B,cardiac output decreased by 13% at 15th min following deliberated hypotension (P<0.01),PaCO_2 and P_(ET)CO_2 decreased slightly as compared with the control values, and returned to baseline or higher than baseline after SNP withdrawal, but P_(a-ET) CO_2 kept unchanged during the entire procedures (P>0.05). It is suggested that PaCO_2 can be evaluated continuously and noninvasively by monitoring end-tidal CO_2 tension during SNP-induced hypotension.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
1996年第6期248-250,共3页
Chinese Journal of Anesthesiology
关键词
控制性降压
硝普钠
普鲁卡因
复合麻醉
Controlled hypotension Sodium nitroprusside End-tidal CO_2 tension Arterial CO_2 tension
