摘要
为观察前列腺素E_1(PGE_1)对腹部手术患者肝功能的影响,将55例术前肝功能正常、准备行择期胃癌根治术的成年患者,随机分成PGE_1组(n=27)和对照组(n=28),在静脉全麻下进行手术,开腹后,PGE_1组,以20～60ng·kg^(-1)·min^(-1)速率持续滴注PGE_1,至止手术结束,而对照组则以相同的速率持续滴注生理盐水,分别于术后第1、3、7、10天测定谷丙转氨酶(GPT)及谷草转氨酶(GOT),结果表明:两组GOT和GPT,在术后第1天都明显上升(P<0.05);对照组GOT和GPT,于术后第1、3天都显著高于PGE_1组的水平(P<0.05)。由此,术中持续滴注PGE_1可以有效地改善腹部手术对肝功能的损伤。
To investigate the effect of prostaglandin E_1 (PGE_1) on the liver function following laparotomy, 55 adult patients with normal liver function, undergoing elective laparotomy for gastric cancer under total intravenous anesthesia ,were randomly allocated to receiving intravenous infusion of PGE_1 at rate of 20 to 60ng·kg^(-1). min^(-1)(group PGE_(1,n)=27), or normal saline (group control, n=28 )from the opening of abdomen to the end of operation,respectively. The serum concentrations of glutamin-pyruvic transaminase (GPT)and glutamic-oxaloacetic transaminase (GOT)were measured postoperatively. The results showed that as compared with the values before the operation,the levels of GPT and GOT increased significantly in both groups on the first postoperative day (P<0.05); the values of GOT and GPT were lower in group PGE_1 than those in group control on the first and third postoperative day(P<0.05). Therefore, continuous intravenous infusion with PGE, during operation can effectively improve the injury of liver function resulting from the laparotomy.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
1996年第7期327-328,共2页
Chinese Journal of Anesthesiology
