摘要
对比研究了吸入ＮＯ与静脉输注ＰＧＥ１治疗肺微血管栓塞肺动脉高压犬的血流动力学效果，结果表明，ＮＯ与ＰＧＥ１均显著降低肺动脉压和肺循环阻力，但ＰＧＥ１显著影响体循环，而ＮＯ组心率、血压和体循环阻力均无明显变化，提示ＮＯ比ＰＧＥ１更具有肺血管扩张选择性，治疗肺动脉高压ＮＯ明显优于ＰＧＥ１。
Toevaluatetheefectsofnitricoxide(NO)onhemodynamicsinpulmonaryhypertensivedogs,eighteenadultmongreldogswithpulmonaryhypertensioninducedbymicroemboli,wererandomlydividedintothreegroups,eachreceivedintravenousnormalsaline,prostaglandinE1(PGE1)orinhaledNOfortwohours.Alhemodynamicparameterswerestableinthecontrolgroup;Thereweresignificantdecreaseinmeanpulmonaryarterypressure(MPAP)andpulmonaryvascularresistanceindex(PVRI)whileheartrate(HR),meansystemicarterypressure(MSAP),systemicvascularresistanceindex(SVRI)toNo,andcardiacindex(CI)remainedstableininhaledNOgroup;PGE1hadsimilarefectonMPAPandPVRI,buthadasingnificantinfluenceonsystemiccirculation.Theresultssuggestthatin-halingNOhasseletivevasculardilatationeffectonpulmonarycirculationandissuperiortoPGE1inthetreatmentofpulmonaryhypertension.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
1996年第11期547-550,共4页
Chinese Journal of Anesthesiology
