摘要
目的探讨环氧化酶-2(COX-2)及血管内皮生长因子(VEGF-C、VEGF-D)在子宫颈癌组织中的表达与淋巴转移的关系。方法采用免疫组织化学SP法,检测45子颈癌组织和15正常宫颈上皮组织中COX-2、VEGF-C和VEGF-D的表达,并结合临床病理资料进行分析。结果宫颈癌组织中COX-2、VEGF-C和VEGF-D的表达明显高于正常宫颈上皮组织(P<0.01),且COX-2的表达与VEGF-C的表达强度显著相关(P<0.01)。COX-2、VEGF-C和VEGF-D的高表达与宫颈癌淋巴结转移有关(P<0.05),与患者年龄、临床分期、组织学类型和肿瘤细胞分化程度无关(P>0.05)。结论子宫颈癌组织中COX-2、VEGF-C和VEGF-D的表达高于正常子宫颈组织,且与淋巴转移关系密切。COX-2过度表达可能通过VEGF的表达参与子宫颈癌淋巴转移的发生。
[Objective] To investigate the relationships between the expressions of Cycloxygenase-2 （COX-2） and vascular endothelial growth factor （VEGF） and the lymphatic metastasis of cervix neoplasm. [Methods] The expressions of COX-2, VEGF-C and VEGF-D in 45 cases of cervix neoplasmtissue and 15 cases of normal cervix tissue were detected by immunohistochemical streptravidin-biothin peroxidase （SP） assay. All of the above results were analyzed along with the pathologic examination. [Results] The expression levels of COX-2, VEGF-C and VEGF-D on cervix neoplasm tissue were significantly higher than those on normal cervix tissue （P 〈0.01）, and the expression level of COX-2 was positively correlated with that of VEGF-C. Moreover, the overexpressions of COX-2, VEGF-C and VEGF-D were related to the lymphatic metastasis （P 〈0.05）. But they had no relation to the patients＇ age, clinical stage, histological category and cell differentiation level （P 〉0.05）. [Conclusions] The overexpressions of COX- 2, VEGF-C and VEGF-D were closely related to the lymphatic metastasis of cervix neoplasm. And the overexpression of COX-2 mediated by the expression of VEGF may participate in the genesis of lymphatic metastasis of cervix neoplasm.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2007年第3期282-284,290,共4页
China Journal of Modern Medicine
关键词
子宫颈癌
环氧化酶-2
血管内皮生长因子C
血管内皮生长因子D
cervix neoplasm
Cycloxygenase-2
vascular endothelial growth factor C
vascular endothelial growth factor D
