摘要
热板法和扭体法测得小鼠“足三里”注射可乐定（ｃｌｏｎｉｄｉｎｅ，ＣＬＮ）镇痛作用显著强于腹腔组。育享宾预处理不能拮抗“足三里”注射的镇痛作用，但明显拮抗了腹腔、皮下、“足三里”旁注射的镇痛效应。股神经和坐骨神经切断侧“足三里”注射ＣＬＮ产生的镇痛作用与健侧“足三里”注射者无明显差别。纳络酮不拮抗ＣＬＮ的镇痛作用。“足三里”及腹腔注射ＣＬＮ产生镇痛时血浆Ｂｅｔａ－内啡呔样物质免疫活性与对照组无明显差别。
Injection of clonidine(CLN)into 'Zusanli'(ST36)point in the mouse had a significantly stronger analgesic effect as compared with intraperitoneal injection,Previous administration of yohimbine could not antagonize the analgesic effect of the injection of CLN into 'Zusanli' point,but antagonized obviously the analgesic effects of CLN intraptritoneal injection.subcutaneous injection and injection into near 'Zusanli' point.There was no significant difference in analgesic effect between injection of CLN into 'Zusanli' points on the side where femoral nerve and sciatic nerve were cut off and on the health side. The analgesic effect of CLN could not be antagonized by naloxone.There was no significant change in plasma β-endorphin-like immunoreactive substances as compared with the control group when injection of CLN into 'Zusanli' (ST36) point and intraperitaneal injection of CLN produced analgesia.
出处
《中国针灸》
CAS
CSCD
北大核心
1996年第7期51-53,共3页
Chinese Acupuncture & Moxibustion
关键词
可乐定
药理学
水针疗法
CLONIDINE /pharmacol,CLONIDINE/admin,ANALGESIA POINT ST36(ZUSANLI)
