摘要
目的评估中国四个大规模抗高血压临床试验的疗效。方法采用固定效应模型进行数据分析。结果分析显示平均治疗时间为3．7a，血压平均降低9／4mmHg。脑卒中危险降低36％（95％CI为25％～46％，P〈0．001），心血管死亡和总死亡减少22％和20％（P〈0．05），总的心血管事件减少33％（P〈0．001）。冠心病事件减少无显著性差异（P〉0．05）。结论抗高血压治疗的效果很大程度上源于脑卒中事件的减少。
Objective To assess the effect of the four large scale antihypertensive clinical trials with an overall study population of 10,457 patients which were held in China. Methods The fixed effect model was used for data analysis. Results A pooled analysis at the individual level showed that the average time of treatment was 3.7 years, after which the average reduction of blood pressure of 9/4 mmHg was found. Overview showed that stroke was reduced by 36% （95% CI 25% -46%, P〈0.001）, cardiovascular death and total deaths were reduced by 22 % and 20 % respectively （P 〈 0.05）, and total cardiovascular events were significantly reduced by 33% （P 〈 0. 001 ）. However, the reduction of CHD was much smaller than the others, and not statistically significant （ P 〉 0.05 ）, and the epidemiologically expected stroke reduction appeared significant. Conclusions The benefit of antihypertensive treatment is obtained mostly from the reduction of incidence of stroke.
出处
《疾病控制杂志》
2007年第1期20-23,共4页
Chinese Journal of Disease Control and Prevention
关键词
随机对照试验
META分析
高血压
Randomized controlled trials
Meta-analysis
Hypertension
