摘要
目的了解宁波市A群脑膜炎奈瑟菌对常用抗生素的敏感性，为流行性脑脊髓膜炎的预防与治疗提供科学依据。方法采用E—test法和KB法，对宁波市2004—2005年分离9株A群脑膜炎奈瑟菌进行药敏试验。结果9株A群脑膜炎奈瑟菌对6种治疗药物青霉素，氨苄西林，头孢曲松，头孢噻肟，美洛培南，氯霉素均敏感，6种预防用药阿奇霉素，米诺环素，萘啶酸、环丙沙星，复方SMZ和利福平中，阿奇霉素敏感，88、9％米诺环素敏感，66．7％利福平敏感，对萘啶酸、环丙沙星，复方SMZ均耐药。结论宁波市2004—2005年分离的流脑菌株对萘啶酸、环丙沙星，复方SMZ已产生耐药性，在当前防治流脑时应慎重使用。提示应加强脑膜炎奈瑟菌监测，合理选择抗生素，为预防和控制提供依据。
Objective To survey the susceptibility of Neisseria Meningitidis Serogroup A isolated in Ningbo City to antimicrobial agents and provide guide for prevention and clinical treatment of epidemic cerebrospinal meningitis. Methods The susceptibility of 9 isolates of Neisseria Meningitidis Serogroup A isolated between 2004 and 2005 to antimicrobial agents were tested with the E - test and K - B method. Results Nine isolates of Neisseria Meningitidis Serogroup A were sensitive to 6 antimicrobial agents for clinical therapy including Penicillin（G）, Ampicillin, Ceftriaxone Sodium, Cefotaxime,meropenem and Chloramphenicol. The 9 strains of Neiserria meningitides serogroup A were sensitive to 6 kinds of preventive drugs including Azitromycin, Minocycline, Nalidixic Acid, Ciprofloxacin, SMZ - Co and Rifampin, 88.9% of the isolates were sensitive to Minocyline and 66.7% sensitive to Rifampin,but all isolates were resistant to Nalidixic Acid, Ciprofloxacin and SMZ- Co. Conclusion All the isolates are sensitive to Minoeycline, Azitromycin and Rifampin which can be used for control of epidemic cerebrospinal meningitis and Nalidixic Acid, Ciprofloxacin and SMZ - Co can be used with caution as the resistance of the isolates determined. Thus propor selection of effective antibacterial agents is fundamentally important for controlling the outbreak of epidemic cerebrospinal meningitis.
出处
《中国热带医学》
CAS
2007年第3期401-402,共2页
China Tropical Medicine
关键词
流行性脑脊髓膜炎
A群脑膜炎萘瑟菌
药物敏感性
Epidemic Cerebrospinal Meningitis
Neisseria Meningitidis Serogroup A
Susceptibility to Antimicrobial Agents
